Bladder wall drug delivery system

• US 9,381,335 B2
• Filed: 03/11/2013
• Issued: 07/05/2016
• Est. Priority Date: 03/21/2012
• Status: Expired due to Fees

• Current Assignee: Astora Women's Health Holdings LLC (Endo International PLC)
• Original Assignee: Ams Research Corporation (Endo International PLC)
• Inventors: Wang, Guangjian, Watschke, Brian P.
• Primary Examiner(s): Eisenberg, Rebecca E
• Application Number:
  US13/793,248
• Publication Number:
  US 20130253477A1
• Time in Patent Office: 1,212 Days
• Field of Search: 604/517, 604/275, 604/279, 604/264, 604/508, 604/523, 604/544
• US Class Current: 1/1
• CPC Class Codes: A61B 1/043 for fluorescence imaging
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61M 2025/0008 having visible markings on its surface, i.e. visible to the naked eye, for any purpose, e.g. insertion depth markers, rotational markers or identification of type
• CPC Class Codes: A61M 2025/0166 Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008

Abstract

A catheter based drug delivery system for minimally invasive delivery of treatment drugs into a bladder wall. The catheter system can include a delivery tip for deforming the bladder wall before forming jets of drug solution that penetrate the bladder wall for needleless delivery of the treatment drugs directly to the diseased tissue. The delivery tip can also have graduated markings for providing visual indicators of the relative depth of the delivery tip in the bladder wall and the alignment of the formed jets with the particular layers of the bladder wall.

Claims

1. A method of delivering drugs into a bladder wall, comprising:

advancing a needleless delivery tip on a catheter into proximity with a bladder wall;

illuminating the bladder wall with a light projection system having a wavelength corresponding to diseased tissue;

identifying the diseased tissue with a micro-camera; and

delivering a treatment drug to the diseased tissue through an orifice in the needleless delivery tip.

2. The method of claim 1, further comprising:

positioning the needleless delivery tip proximate the diseased tissue.

3. The method of claim 1, further comprising:

pushing the needleless delivery tip against the bladder wall such that the bladder wall deforms about the needleless delivery tip.

4. The method of claim 3, wherein the needleless delivery tip includes a plurality of graduated markers, wherein each graduated marker corresponds to a predetermined depth of the orifice with respect to the bladder wall, the method further comprising:

aligning a selected graduated marker with the deformed bladder wall.

5. The method of claim 1, further comprising:

administering a dye to the bladder wall, wherein said dye is selected to promote visualization of the diseased tissue.

6. The method of claim 1, wherein delivery of the treatment drug further comprises:

pressurizing the treatment drug such that a pressurized jet of treatment drug is delivered through the orifice.

7. A method of delivering drugs into a bladder wall, comprising:

advancing a needleless delivery tip on a catheter into proximity with a bladder wall;

pushing the needleless delivery tip against the bladder wall such that the bladder wall deforms about the needleless delivery tip;

aligning a selected one of a plurality of graduated markers on the needleless delivery tip with the deformed bladder wall, wherein each of the plurality of graduated markers corresponds to a predetermined depth of the orifice with respect to the bladder wall; and

delivering a treatment drug into the bladder wall through an orifice in the needleless delivery tip.

8. The method of claim 7, further comprising:

illuminating the bladder wall with a light projection system having a wavelength corresponding to diseased tissue; and

identifying the diseased tissue with a micro-camera.

9. The method of claim 8, further comprising:

positioning the needleless delivery tip proximate the diseased tissue.

10. The method of claim 8, further comprising:

administering a dye to the bladder wall, wherein said dye is selected to promote visualization of the diseased tissue.

11. The method of claim 7, further comprising:

pressurizing the treatment drug such that a pressurized jet of treatment drug is delivered through the orifice.

12. A bladder treatment delivery system, comprising:

a delivery catheter having a needleless delivery tip, the needleless delivery tip including a delivery orifice, a light projection system and a micro camera, the light projection system adapted to provide a selected light wavelength, where said light wavelength corresponds to a type of diseased tissue on a bladder wall and said micro camera is adapted to image the light wavelength and identify the diseased tissue such that said delivery orifice can be positioned proximate the diseased tissue; and

a control system for pressurizing a treatment fluid such that said treatment fluid flows through the delivery catheter and into the diseased tissue through the delivery orifice.

13. The bladder treatment delivery system of claim 12, wherein the needleless delivery tip includes a plurality of graduated markers, wherein each graduated marker corresponds to a predetermined depth of the delivery orifice with respect to the bladder wall.

14. The bladder treatment delivery system of claim 13, wherein the needleless delivery tip is pressed against the bladder wall to deform the bladder wall such that a selected one of the graduated markers is aligned with the deformed bladder wall for delivering the treatment fluid to the desired predetermined depth.

15. The bladder treatment delivery system of claim 12, further comprising:

a dye selected to promote visualization of the diseased tissue by the micro camera.

16. The bladder treatment delivery system of claim 12, wherein the control system comprises a manual control for adjusting the pressure of the treatment fluid supplied to the needleless delivery tip.

17. The bladder treatment delivery system of claim 12, wherein the delivery orifice is shaped to act as a jet nozzle.

18. A bladder treatment delivery system, comprising:

a delivery catheter having a needleless delivery tip including a delivery orifice, the needleless delivery tip including a plurality of graduated markers, each graduated marker corresponding to a predetermined depth of the delivery orifice with respect to a bladder wall; and

a control system for pressurizing a treatment fluid such that said treatment fluid flows through the delivery catheter and is injected to diseased tissue on the bladder wall.

19. The bladder treatment delivery system of claim 18, wherein the needleless delivery tip includes a light projection system and a micro camera, the light projection system adapted to provide a selected light wavelength, where said light wavelength corresponds to the diseased tissue on the bladder wall and said micro camera is adapted to image the light wavelength and identify the diseased tissue such that said delivery orifice can be positioned proximate the diseased tissue.

20. The bladder treatment delivery system of claim 19, further comprising:

a dye selected to promote visualization of the diseased tissue by the micro camera.

21. The bladder treatment delivery system of claim 18, wherein the needleless delivery tip is pressed against the bladder wall to deform the bladder wall such that a selected one of the graduated markers is aligned with the deformed bladder wall for delivering the treatment fluid to the desired predetermined depth.

22. The bladder treatment delivery system of claim 18, wherein the control system comprises a manual control for adjusting the pressure of the treatment fluid supplied to the needleless delivery tip.

23. The bladder treatment delivery system of claim 18, wherein the delivery orifice is shaped to act as a jet nozzle.