Relaxin fusion polypeptides and uses thereof
First Claim
1. A fusion polypeptide having Relaxin activity comprising A-L-B,whereinB comprises a Relaxin 2 B chain polypeptide,A comprises a Relaxin 2 A chain polypeptide, andL is a linker polypeptide, wherein the linker polypeptide L is 6-14 amino acids in length.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A- and B-chains are connected by a linker peptide. The invention further provides Relaxin fusion polypeptides with extended half-life. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides.
59 Citations
17 Claims
-
1. A fusion polypeptide having Relaxin activity comprising A-L-B,
wherein B comprises a Relaxin 2 B chain polypeptide, A comprises a Relaxin 2 A chain polypeptide, and L is a linker polypeptide, wherein the linker polypeptide L is 6-14 amino acids in length.
-
14. A polynucleotide encoding a fusion polypeptide having Relaxin activity comprising A-L-B, wherein
B comprises a Relaxin 2 B chain polypeptide, A comprises a Relaxin 2 A chain polypeptide, and L is a linker polypeptide, wherein the linker polypeptide L is 6-14 amino acids in length.
Specification