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nucleic acid polymerases

  • US 9,382,522 B2
  • Filed: 08/19/2009
  • Issued: 07/05/2016
  • Est. Priority Date: 03/12/2004
  • Status: Expired due to Fees
First Claim
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1. An isolated derivative nucleic acid polymerase comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO:

  • 14, wherein said amino acid sequence comprises an Asp in place of Gly at a position corresponding to amino acid position 46 of SEQ ID NO;

    13, wherein said amino acid sequence further comprises an Arg at a position corresponding to amino acid position 250 of SEQ ID NO;

    13, and wherein said derivative nucleic acid polymerase has decreased 5′

    -3′

    exonuclease activity compared to a wild type nucleic acid polymerase comprising SEQ ID NO;

    14.

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