Method and device for processing a time-dependent measurement signal

• US 9,383,288 B2
• Filed: 05/05/2014
• Issued: 07/05/2016
• Est. Priority Date: 06/26/2008
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Solem, Kristian, Olde, Bo
• Primary Examiner(s): DEAK, LESLIE R
• Application Number:
  US14/270,246
• Publication Number:
  US 20150019170A1
• Time in Patent Office: 792 Days
• Field of Search: 604/4.01, 604/5.01, 604/6.09, 604/6.1, 604/6.11
• US Class Current: 1/1
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3656 Monitoring patency or flow at connection sites; Detecting disconnections
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 1/3661 for haemodialysis
• CPC Class Codes: G01L 27/002 Calibrating, i.e. establishing true relation between transducer output value and value to be measured, zeroing, linearising or span error determination
• CPC Class Codes: G01M 3/2815 using pressure measurements
• CPC Class Codes: G01M 3/2846 for tubes G01M3/30 takes precedence
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80

Abstract

A monitoring device is arranged to receive a time-dependent measurement signal from a pressure sensor in a fluid containing system, which is associated with a first pulse generator and a second pulse generator. The pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator. The monitoring device is configured to process the measurement signal to remove the first pulse. In this process, the monitoring device receives the measurement signal, obtains a first pulse profile which is a predicted temporal signal profile of the first pulse, and filters the measurement signal in the time-domain, using the first pulse profile, to essentially eliminate the first pulse while retaining the second pulse. The fluid containing system may include an extracorporeal blood flow circuit and a blood circuit of a human patient.

Claims

1. A device for processing a time-dependent measurement signal obtained from a pressure sensor in a fluid containing system associated with a first pulse generator and a second pulse generator, wherein the pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator, wherein the fluid containing system comprises an extracorporeal blood flow circuit for connection to a blood system in a human body, wherein the first pulse generator comprises a pumping device in the extracorporeal blood flow circuit, and wherein the second pulse generator comprises a physiological pulse generator in the human body, said device comprising:

an input for the time-dependent measurement signal;

a signal processor connected to said input and comprising a processing module configured to obtain a first pulse profile which is a predicted temporal signal profile of the first pulse, and to filter the time-dependent measurement signal in a time-domain to output an error signal in which the first pulse is essentially eliminated while the second pulse is retained; and

an adaptive filter;

wherein the signal processor is further configured to;

supply the first pulse profile as input to the adaptive filter;

calculate the error signal as a difference between the measurement signal and an output signal of the adaptive filter; and

provide the error signal as input to the adaptive filter, whereby the adaptive filter is arranged to essentially eliminate the first pulse in the error signal.

2. The device of claim 1, which is configured to obtain the first pulse profile in a reference measurement in said fluid containing system, wherein the signal processor is configured to, during the reference measurement:

operate the first pulse generator to generate at least one first pulse, and obtain the first pulse profile from a reference signal generated by a reference pressure sensor in the fluid containing system.

3. The device of claim 2, wherein the signal processor is configured to operate the first pulse generator to generate a sequence of first pulses during the reference measurement, and obtain the first pulse profile by identifying and averaging a set of first pulse segments in the reference signal.

4. The device of claim 2, wherein the signal processor is configured to effect the reference measurement intermittently during operation of the fluid containing system to provide an updated first pulse profile.

5. The device of claim 2, wherein the signal processor is configured to obtain the reference signal from said pressure sensor.

6. The device of claim 1, wherein the signal processor is configured to obtain the first pulse profile based on a predetermined signal profile.

7. The device of claim 6, wherein the signal processor is configured to obtain the first pulse profile by modifying the predetermined signal profile according to a mathematical model based on a current value of one or more system parameters of the fluid containing system.

8. The device of claim 2, wherein the signal processor is configured to operate the fluid containing system, during the reference measurement, such that the reference signal contains a first pulse and no second pulse.

9. The device of claim 2, wherein the signal processor is configured to effect the reference measurement during a priming phase, in which the extracorporeal blood flow circuit is detached from the human blood system and a priming fluid is pumped through the extracorporeal blood flow circuit, and wherein the signal processor is configured to operate the fluid containing system, during the reference measurement, such that the reference signal from the reference pressure sensor contains a first pulse and no second pulse.

10. The device of claim 2, wherein the signal processor is configured to, during the reference measurement:

obtain a combined pulse profile based on a first reference signal containing a first pulse and a second pulse;

obtain a second pulse profile based on a second reference signal containing a second pulse and no first pulse, and obtain the predicted temporal signal profile by subtracting the second pulse profile from the combined pulse profile.

11. The device of claim 1, wherein the signal processor is further configured to obtain a current value of one or more system parameters of the fluid containing system, and obtain the first pulse profile as a function of the current value.

12. The device of claim 11, wherein the signal processor is configured to:

identify, based on the current value, one or more reference profiles in a reference database; and

obtain the first pulse profile based on said one or more reference profiles.

13. The device of claim 12, wherein said one or more system parameters is indicative of the rate of first pulses in the fluid containing system.

14. The device of claim 13, wherein the one or more system parameters is indicative of a pump frequency of the pumping device.

15. The device of claim 12, wherein each reference profile in the reference database is obtained by a reference measurement in the fluid containing system for a respective value of said one or more system parameters.

16. The device of claim 11, wherein the signal processor is further configured to:

identify, based on the current value, one or more combinations of energy and phase angle data in a reference database, and obtain the first pulse profile based on said one or more combinations of energy and phase angle data.

17. The device of claim 16, wherein the signal processor is configured to obtain the first pulse profile by combining a set of sinusoids of different frequencies, wherein the amplitude and phase angle of each sinusoid is given by said one or more combinations of energy and phase angle data.

18. The device of claim 11, wherein the signal processor is configured to obtain the first pulse profile by inputting the current value into an algorithm which is configured to calculate a response of the pressure sensor based on a mathematical model of the fluid containing system.

19. The device of claim 1, wherein the adaptive filter comprises a finite impulse response filter with filter coefficients that operate on the first pulse profile to generate the output signal, and an adaptive algorithm which optimizes the filter coefficients as a function of the error signal and the first pulse profile.

20. The device of claim 19, wherein the adaptive filter is configured to form the output signal as a linear combination of M shifted first pulse profiles, wherein M is the length of the finite impulse response filter.

21. The device of claim 20, wherein the adaptive filter is configured to re-scale, in amplitude, at least one of the M shifted first pulse profiles being linearly combined.

22. The device of claim 19, wherein the signal processor is configured to control the adaptive filter to lock the filter coefficients, based on a comparison of the rate, the amplitude, or the rate and amplitude of the second pulses to a limit value.

23. The device of claim 1, wherein the second pulse generator is at least one of a heart, a breathing system, and a vasomotor affected by an autonomic nervous system.

24. The device of claim 1, wherein the extracorporeal blood flow circuit comprises an arterial access device, a blood processing device, and a venous access device, wherein the human blood system comprises a blood vessel access, wherein the arterial access device is configured to be connected to the human blood system, wherein the venous access device is configured to be connected to the blood vessel access to form a fluid connection, and wherein the pumping device is arranged in the extracorporeal blood flow circuit to pump blood from the arterial access device through the blood processing device to the venous access device, said device being further configured to receive the time-dependent measurement signal either from a venous pressure sensor located downstream of the pumping device, or from an arterial pressure sensor located upstream of the pumping device.

25. A computer-readable medium comprising instructions for causing a computer to perform a method for processing a time-dependent measurement signal, said method comprising:

receiving the time-dependent measurement signal from a pressure sensor in a fluid containing system associated with a first pulse generator and a second pulse generator, wherein the pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator, wherein the fluid containing system comprises an extracorporeal blood flow circuit for connection to a blood system in a human body, wherein the first pulse generator comprises a pumping device in the extracorporeal blood flow circuit, and wherein the second pulse generator comprises a physiological pulse generator in the human body,

obtaining a first pulse profile which is a predicted temporal signal profile of the first pulse, and

filtering the time-dependent measurement signal in a time-domain to output an error signal in which the first pulse is essentially eliminated while the second pulse is retained, wherein said filtering comprises;

supplying the first pulse profile as input to an adaptive filter;

calculating the error signal as a difference between the measurement signal and an output signal of the adaptive filter; and

providing the error signal as input to the adaptive filter, whereby the adaptive filter is arranged to essentially eliminate the first pulse in the error signal.

26. A device for processing a time-dependent measurement signal obtained from a pressure sensor in a fluid containing system associated with a first pulse generator and a second pulse generator, wherein the pressure sensor is arranged in the fluid containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the second pulse generator, wherein the fluid containing system comprises an extracorporeal blood flow circuit for connection to a blood system in a human body, wherein the first pulse generator comprises a pumping device in the extracorporeal blood flow circuit, and wherein the second pulse generator comprises a physiological pulse generator in the human body, said device comprising:

means for receiving the time-dependent measurement signal,

means for obtaining a first pulse profile which is a predicted temporal signal profile of the first pulse, and

means for filtering the time-dependent measurement signal in a time-domain to output an error signal in which the first pulse is essentially eliminated while the second pulse is retained, wherein said means for filtering is further configured to supply the first pulse profile as input to an adaptive filter;

calculate the error signal as a difference between the measurement signal and an output signal of the adaptive filter; and

provide the error signal as input to the adaptive filter, whereby the adaptive filter is arranged to essentially eliminate the first pulse in the error signal.