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Method and apparatus for analysis and sorting of polynucleotides based on size

  • US 9,383,337 B2
  • Filed: 01/14/2013
  • Issued: 07/05/2016
  • Est. Priority Date: 09/25/1996
  • Status: Expired due to Fees
First Claim
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1. A method of analyzing an individual polynucleotide single-stranded DNA molecule in a solution using a microfluidic device, the method comprising :

  • transporting the individual molecule through a detection region having a volume of between 1 femtoliter and 1 picoliter that is positioned in a microfluidic channel of the device without hydrodynamically focusing the solution with a sheath fluid, and without previous size separation of polynucleotides in the solution; and

    determining the size of the molecule as it passes through the detection region.

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