Apparatus and method for selectively heating a deposit in fatty tissue in a body

• US 9,387,036 B2
• Filed: 12/23/2009
• Issued: 07/12/2016
• Est. Priority Date: 05/14/2007
• Status: Active Grant

• Current Assignee: Pyrexar Medical, Inc.
• Original Assignee: Pyrexar Medical, Inc.
• Inventors: Turner, Paul F., Hagmann, Mark
• Primary Examiner(s): HUPCZEY, JR, RONALD JAMES
• Application Number:
  US12/646,729
• Publication Number:
  US 20100100092A1
• Time in Patent Office: 2,393 Days
• Field of Search: 607/101
• US Class Current: 1/1
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2018/00464 Subcutaneous fat, e.g. liposuction, lipolysis
• CPC Class Codes: A61N 5/025 Warming the body, e.g. hyperthermia treatment

Abstract

Heat treatment is applied to tissue in need of such treatment which is surrounded by tissue not in need of such treatment, by positioning a deposit within the surrounding tissue adjacent the tissue in need of treatment. The dielectric constant and/or the conductivity of the deposit is greater than that of the surrounding tissue. A radio frequency antenna or antenna array directs a radio frequency signal at a selected frequency into the deposit. The deposit has a diameter within a range of about 0.5 times to about 0.16 times the wavelength of the radio frequency signal within the surrounding tissue. The deposit is heated, at least partially through resonant heating, to a temperature greater than the surrounding tissue to apply heat treatment to the tissue in need of treatment. The deposit may take the form of a balloon of a Mammosite® type device to provide hyperthermia treatment in conjunction with radiation treatment of a breast after a lumpectomy.

Claims

1. An apparatus for providing hyperthermia treatments to a breast having fatty mammary tissue surrounding tissue in need of said hyperthermia treatment, said fatty mammary tissue having a dielectric constant and a conductivity, comprising:

a cavity for receiving the breast therein;

a first radio frequency antenna operable to direct a radio frequency signal at a selected frequency into the breast received in the cavity, said radio frequency signal having a wavelength within the fatty mammary tissue; and

a deposit adapted to be positioned in the fatty mammary tissue of the breast adjacent the tissue in need of said hyperthermia treatment, said deposit having at least one of a dielectric constant and conductivity greater than the dielectric constant and conductivity of the fatty mammary tissue and having a diameter within a range of about 0.5 times to 0.16 times the wavelength of the radio frequency signal within the fatty mammary tissue whereby the deposit, when positioned in the fatty mammary tissue adjacent the tissue in need of said hyperthermia treatment, will be heated, at least partially by resonant heating, by the radio frequency signal, the heated deposit then supplying heat for said hyperthermia treatment to the tissue adjacent the deposit.

2. The apparatus of claim 1, wherein the deposit includes a material having at least one of a dielectric constant and a conductivity greater than that of the fatty mammary tissue surrounding the deposit.

3. The apparatus of claim 1, wherein the deposit includes an inflatable balloon adapted to be inflated with a material having at least one of a dielectric constant and a conductivity greater than that of the mammary tissue surrounding the deposit.

4. The apparatus of claim 3, wherein the inflatable balloon is positioned around a portion of a catheter adapted to be inserted into the breast to position the inflatable balloon adjacent the tissue to be treated.

5. The apparatus of claim 4, wherein the material is an inflation material, wherein the catheter includes an inflation passage therein through which the inflation material is passed to inflate the inflatable balloon after it is positioned adjacent the tissue to be treated.

6. The apparatus of claim 5, wherein the catheter includes a passage therein extending along the catheter to a position aligned with the inside of the inflatable balloon and adapted to receive a temperature measuring probe therein so as to place a temperature sensor in position to measure the approximate temperature of the inflation material in the balloon.

7. The apparatus of claim 5, wherein the catheter includes a passage therein extending along the catheter to a position aligned with the inside of the inflatable balloon and adapted to alternately receive a temperature measuring probe therein so as to place a temperature sensor in position to measure the approximate temperature of the inflation material in the balloon and a high dose radiation emitter.

8. The apparatus of claim 1, wherein the selected frequency of the radio frequency signal is about 915 MHz.

9. The apparatus of claim 1, wherein the deposit has a diameter in a range of about 2.3 to 7 centimeters.

10. The apparatus of claim 1, wherein the radio frequency antenna is an antenna array operable to direct a circularly polarized radio frequency electromagnetic field into the breast.

26. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 1, wherein the source of radio frequency radiation is an applicator including a cavity for receiving a body part therein and having a radio frequency antenna operable to direct radio frequency radiation into the body part received in the cavity.

11. Apparatus for providing heat treatment to living tissue in need of such heat treatment and surrounded by living tissue not in need of such heat treatment, said living tissue not in need of such heat treatment having a dielectric constant and a conductivity, comprising:

a deposit of material in a form to be positioned in the living tissue adjacent the tissue in need of heat treatment, said deposit of material having a diameter, dielectric constant, and conductivity; and

a source of radio frequency radiation adapted to direct the radio frequency radiation through said living tissue not in need of such heat treatment into the deposit of material when the deposit of material is positioned in the living tissue adjacent the tissue in need of heat treatment, said radio frequency radiation having a wavelength when passing through the living tissue not in need of such heat treatment;

wherein

the diameter of the deposit of material is within a range of about 0.5 times to about 0.16 times the wavelength of the radio frequency signal within the living tissue not in need of heat treatment and at least one of the dielectric constant and the conductivity of the deposit of material is greater than the dielectric constant and the conductivity of the living tissue not in need of heat treatment to selectively heat the deposit of material to a temperature greater than the surrounding tissue not in need of heat treatment at least partially through resonant heating of the deposit of material from the radio frequency signal, the heated deposit of material then supplying heat for heat treatment to the tissue adjacent the deposit of material.

12. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 11, wherein the deposit of material includes a container with a filler material held within the container.

13. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 12, wherein the container is an elastic material.

14. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 13, wherein the container is an inflatable balloon.

15. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 14, wherein the inflatable balloon includes an inflation inlet.

16. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 15, wherein the inflatable balloon is mounted to the distal end portion of a catheter and the inflation inlet to the balloon is from a catheter inflation passage.

17. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 16, wherein the filler material held within the container is an inflation fluid held within the inflatable balloon, and wherein the inflatable balloon is inflatable by passing the inflation fluid into the balloon through the catheter inflation passage.

18. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 17, wherein the inflation fluid is saline solution.

19. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 18, wherein the deposit of material is adapted to be implanted into the living tissue.

20. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 19, wherein the deposit is implanted into the living tissue by inserting the distal end portion of the catheter into the living tissue.

21. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 20, wherein the catheter additionally includes an insertion passage extending along the catheter to a position aligned with the inside of the balloon.

22. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 21, wherein the insertion passage is adapted to receive a temperature sensing probe with a temperature sensor positioned inside the insertion passage aligned with the inside of the balloon.

23. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 21, wherein the insertion passage is adapted to alternately receive a high dose radiation emitter and a temperature sensing probe.

24. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 21, wherein the insertion passage is adapted to receive the source of radio frequency radiation positioned inside the insertion passage at a position aligned with the inside of the balloon.

25. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 11, wherein the source of radio frequency radiation is positioned within the deposit to direct radio frequency radiation through the deposit toward the surrounding tissue not in need of treatment.

27. Apparatus for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such treatment according to claim 11, wherein the radio frequency antenna is an antenna array operable to direct a circularly polarized radio frequency electromagnetic field into the deposit.

28. A method for providing heat treatment to living tissue in need of such treatment and surrounded by living tissue not in need of such heat treatment with the tissue not in need of such treatment having a dielectric constant and a conductivity, comprising:

inserting a deposit of material in the living tissue adjacent the tissue in need of heat treatment, said deposit having a size, dielectric constant, and conductivity with at least one of the dielectric constant and conductivity being greater than the dielectric constant and conductivity of the tissue not in need of heat treatment; and

directing radio frequency radiation into the deposit, said radio frequency radiation having a wavelength within the living tissue not in need of such heat treatment;

wherein a diameter of the deposit is within a range of about 0.5 times to 0.16 times the wavelength of the radio frequency signal within the living tissue not in need of such heat treatment.

29. A method of treating breast cancer comprising:

performing a lumpectomy to remove a cancerous tumor from the breast resulting in a cavity in the breast from where the cancerous tumor was removed which is surrounded by fatty mammary tissue, said fatty mammary tissue having a dielectric constant and a conductivity;

inserting a deposit of material within the cavity adjacent tissue surrounding the cavity, said deposit material having a dielectric constant and conductivity with at least one of the dielectric constant and conductivity greater than the dielectric constant and conductivity of the fatty mammary tissue;

directing radio frequency radiation into the deposit, said radio frequency radiation having a wavelength within the surrounding fatty mammary tissue;

wherein

a diameter of the deposit is within a range of about 0.5 times to 0.16 times the wavelength of the radio frequency signal within the fatty mammary tissue, the heated deposit then providing hyperthermia treatment to the tissue adjacent the cavity.

30. A method of treating breast cancer according to claim 29, additionally including the step of applying radiation to the tissue in need of treatment, and coordinating the step of applying the radiation and the step of providing hyperthermia treatment so that the hyperthermia treatment increases the effectiveness of the radiation treatment.

31. A method of treating breast cancer according to claim 29, additionally including the step of applying chemotherapy to the tissue in need of treatment, and coordinating the step of applying the chemotherapy and the step of providing hyperthermia treatment so that the hyperthermia treatment increases the effectiveness of the chemotherapy.