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Hyperthermia treatment and probe therefor

  • US 9,387,042 B2
  • Filed: 07/01/2013
  • Issued: 07/12/2016
  • Est. Priority Date: 06/15/2000
  • Status: Expired due to Term
First Claim
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1. A method of in vivo hyperthermia treatment of a targeted area of brain target tissue, the method comprising:

  • imaging the brain target tissue with a magnetic resonance imaging (MRI) system;

    positioning a hyperthermia treatment probe in or proximate to the targeted area of the brain target tissue based on the imaging;

    operating a power output source, by a device controller, to heat the targeted area of the brain target tissue with the hyperthermia treatment probe;

    monitoring, by the device controller during the heating, changes in temperature in real time of a volume of tissue that includes the targeted area of the brain target tissue to determine an amount of the heating applied to the targeted area of the brain target tissue, wherein monitoring comprises receiving information from the MRI system indicative of temperatures, and determining changes in temperature in both the targeted area and a portion of surrounding non-target tissue;

    during monitoring,identifying, by the device controller, a difference between a penetration depth of the heating and a boundary of the targeted area,adjusting, by the device controller responsive to identifying the difference between the penetration depth and the boundary, the power output source of the hyperthermia treatment probe, andidentifying, by the device controller, the amount of the heating in the targeted area has reached a predetermined amount; and

    terminating, by the device controller responsive to identifying the amount of the heating in the targeted area has reached the predetermined amount, the power output source.

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