Treatment of skin, including aging skin, to improve appearance

• US 9,387,159 B2
• Filed: 03/13/2013
• Issued: 07/12/2016
• Est. Priority Date: 03/13/2013
• Status: Active Grant

• Current Assignee: Transdermal Biotechnology, Inc.
• Original Assignee: Transdermal Biotechnology, Inc.
• Inventors: Perricone, Nicholas V.
• Primary Examiner(s): Maewall, Snigdha
• Application Number:
  US13/801,446
• Publication Number:
  US 20140271809A1
• Time in Patent Office: 1,217 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/596 Mixtures of surface active compounds
• CPC Class Codes: A61K 2800/78 Enzyme modulators, e.g. Enzyme agonists
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/066 TRH, thyroliberin, thyrotropin releasing hormone
• CPC Class Codes: A61K 8/0216 Solid or semisolid forms
• CPC Class Codes: A61K 8/0295 Liquid crystals
• CPC Class Codes: A61K 8/14 Liposomes; Vesicles
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/553 Phospholipids, e.g. lecithin
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61Q 19/004 Aftersun preparations
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention generally relates to compositions and methods for transdermal delivery, treatment of skin, and improving the appearance of skin. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

Claims

1. A method of improving skin appearance, comprising:

administering, to the skin of a subject, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH) and molecular nitric oxide to improve skin appearance, and a carrier having a phosphatidylcholine component entrapping the molecular nitric oxide, wherein the molecular nitric oxide is present within the carrier as a gas or bound by hydrogen bonds or van der Waals forces, wherein the composition is stable at room temperature.

2. The method of claim 1, wherein the skin of the subject is aging skin.

3. The method of claim 1, wherein the skin of the subject is wrinkled.

4. The method of claim 1, wherein the skin has been damaged due to exposure to ultraviolet light.

5. The method of claim 1, wherein the skin is sunburned skin.

6. The method of claim 1, wherein the phosphatidylcholine carrier stabilizes the nitric oxide at a temperature at or lower than 80°

C.

7. The method of claim 1, wherein the composition comprises a liquid crystal structure comprising the phosphatidylcholine.

8. The method of claim 7, wherein at least a portion of the liquid crystal structure is multilamellar.

9. A method of improving skin appearance, comprising contacting the skin of a subject with a composition comprising:

an emulsion comprising a first phase comprising TRH, molecular nitric oxide and lecithin, and a second phase comprising an emulsifier, wherein the lecithin is present at least about 0.25% by weight of the composition, wherein the first phase comprises no more than about 250 ppm of water by weight of the composition, and wherein the molecular nitric oxide is present within the emulsion as a gas or bound by hydrogen bonds or van der Waals forces to the lecithin.

10. The method of claim 9, wherein the skin of the subject is aging skin.

11. The method of claim 9, wherein the first phase forms discrete vesicles contained within the second phase.

12. The method of claim 11, wherein the first phase forms liposomes contained within the second phase.

13. The method of claim 12, wherein the first phase forms multilamellar liposomes contained within the second phase.

14. The method of claim 9, wherein the nitric oxide is present at at least about 0.5% by weight of the composition without nitric oxide.

15. The method of claim 9, wherein at least some of the nitric oxide is present within the first phase bound to phosphatidylcholine.

16. The method of claim 9, wherein the lecithin comprises a phosphatidylcholine.

17. The method of claim 16, wherein at least some of the phosphatidylcholine comprises a polyenylphosphatidylcholine.

18. The method of claim 9, wherein the first phase comprises a fatty acid ester.

19. A method, comprising:

administering, topically to the skin of a subject, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH), phosphatidycholine and molecular nitric oxide to improve skin appearance of the subject, wherein the composition is a cream, a gel, a lotion, or an ointment, wherein the composition comprises no more than about 250 ppm of water by weight of the composition.

20. The method of claim 19, wherein the skin of the subject is aging skin, wrinkled skin, or sunburned skin.

21. The method of claim 19, wherein the skin has been damaged due to exposure to ultraviolet light.

22. The method of claim 19, wherein the composition comprises a liquid crystal structure comprising the phosphatidylcholine.

23. The method of claim 22, wherein at least a portion of the liquid crystal structure is multilamellar.

24. The method of claim 19, wherein at least some of the phosphatidylcholine comprises a polyenylphosphatidylcholine.