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Pharmaceutical formulation containing gelling agent

  • US 9,387,173 B2
  • Filed: 03/16/2015
  • Issued: 07/12/2016
  • Est. Priority Date: 08/06/2001
  • Status: Expired due to Term
First Claim
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1. A controlled release oral solid dosage form comprising:

  • a first population of particles comprising hydrocodone bitartrate and an ammonio methacrylate copolymer and a second population of particles comprising polyethylene oxide and coated with a coating, whereinthe particles of the first population are free from polyethylene oxide;

    the particles of the second population have a diameter from about 0.5 mm to about 2 mm and are free from hydrocodone bitartrate;

    polyethylene oxide is releasable from the particles of the second population in an effective amount to impart a viscosity from 10 cP to 5000 cP when the dosage form is crushed and dissolved in from about 0.5 ml to about 10 ml of an aqueous liquid; and

    hydrocodone bitartrate is the only drug in the dosage form;

    the dosage form is a capsule.

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