Therapeutic compositions for bone repair
First Claim
1. A method for decreasing bone resorption or increasing bone formation or promoting bone healing at a site in the body of a diabetic mammal in need thereof comprising, administering at or near the site a biodegradable polymer comprising repeating units of formula (Ia) in the polymer backbone:
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Abstract
Individuals having diabetes are more prone to fractures, periodontitis, and other bone related issues as compared to healthy individuals. Furthermore, bone healing in diabetic patients is prolonged. The invention provides a method for decreasing bone resorption or increasing bone formation or promoting bone healing in diabetic patients. In particular, a biodegradeable polymer, such as a polyanhydride salicylate is administered at or near a bone defect site, and upon hydrolysis of the polymer will releases biologically active salicylic acid.
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Citations
17 Claims
- 1. A method for decreasing bone resorption or increasing bone formation or promoting bone healing at a site in the body of a diabetic mammal in need thereof comprising, administering at or near the site a biodegradable polymer comprising repeating units of formula (Ia) in the polymer backbone:
Specification