One-component bone cement pastes and methods for curing them

• US 9,387,275 B2
• Filed: 10/21/2008
• Issued: 07/12/2016
• Est. Priority Date: 10/22/2007
• Status: Active Grant

• Current Assignee: Heraeus Medical GmbH (Heraeus Holding GMBH)
• Original Assignee: Heraeus Medical GmbH (Heraeus Holding GMBH)
• Inventors: Vogt, Sebastian, Buchner, Hubert
• Primary Examiner(s): Tran, Susan
• Assistant Examiner(s): CRAIGO, WILLIAM A
• Application Number:
  US12/255,224
• Publication Number:
  US 20090105144A1
• Time in Patent Office: 2,821 Days
• Field of Search: 514/8.2, 252/500, 252/513, 252/519.33, 523/117, 525/50
• US Class Current: 1/1
• CPC Class Codes: A61L 24/0089 containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084
• CPC Class Codes: A61L 24/0094 containing macromolecular fillers
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters

Abstract

One-component bone cement pastes, containing:

AI at least one methacrylate monomer suitable for radical polymerization;

AII at least one polymer that is soluble in AI;

AIII at least one particulate polymer that is insoluble in AI and has a particle size of less than 500 μm;

optionally AIV at least one radical-forming initiator or at least one radical initiator that is soluble in AI and subject to thermal decomposition;

optionally AV at least one electrically conductive radio-opaquer, in the form of ferromagnetic particles.

Claims

1. A one-component polymethylmethacrylate bone cement paste consisting of

(i) at least one methacrylate monomer selected from the group consisting of butan-1,3-diol-dimethacrylate, butan-1,4-diol-dimethacrylate, and hexan-1,6-diol-dimethacrylate;

(ii) at least one polymer that is soluble in the methacrylate monomer;

(iii) at least one particulate polymer selected from the group consisting of cross-linked poly-methylmethacrylate and cross-linked poly-methylmethacrylate-co-methylacrylate, wherein the particulate polymer is insoluble in the methacrylate monomer and having a particle size of less than 500 μ

m;

(iv) at least one radical initiator that is soluble in the methacrylate monomer and subject to thermal decomposition;

(v) at least one electrically conductive radio-opaquer;

(vi) optionally at least one additional radio-opaquer;

(vii) optionally at least one pharmaceutical agent; and

(viii) optionally at least one biocompatible elastomer that is particulate or soluble in the methacrylate monomer/methacrylate monomers;

wherein the ratio of said at least one methacrylate monomer to soluble polymer to particulate insoluble polymer to radical initiator to electrically conductive radio-opaquer is 25-50;

2-35;

40-70;

0.5-4.0;

2.0-20 based on the weight of the paste.

2. Bone cement paste according to claim 1, wherein said at least one radical initiator that is soluble in the methacrylate monomer and subject to thermal decomposition can be activated.

3. Bone cement paste according to claim 1, wherein said electrically conductive radio-opaquer is present and are particles having a particle size of 0.5 to 500 μ

m of cobalt, iron, NdFeB, SmCo, cobalt-chromium steel, zirconium, hafnium, titanium, titanium-aluminum-silicon alloys, or titanium-niobium alloys.

4. Bone cement paste according to claim 3, wherein said electrical conductive radio-opaquer is iron in the form of ferromagnetic particles.

5. Bone cement paste according to claim 1, wherein the methacrylate monomer is suited for distillation.

6. Bone cement paste according to claim 1, wherein the soluble polymer is a poly-methylmethacrylate-co-polymer.

7. Bone cement paste according to claim 6, wherein the soluble polymer is poly-methylmethacrylate-co-methylacrylate or poly-methyl methacrylate-co-styrene.

8. Bone cement paste according to claim 1, wherein said at least one additional radio-opaquer is present and is selected from the group consisting of zirconium dioxide, barium sulfate, tantalum, and biocompatible calcium salts.

9. Bone cement paste according to claim 1, wherein said at least one pharmaceutical agent is present and is selected from the group consisting of antibiotics, hormones, growth factors, and antiphlogistics.

10. Bone cement paste according to claim 1, wherein said at least one biocompatible elastomer that is particulate or soluble in the methacrylate monomer is present.

11. Bone cement paste according to claim 10, wherein said biocompatible elastomer is polybutadiene or poly-butadiene-co-styrene.

12. Method for curing a bone cement paste comprising exposing a bone cement paste according to claim 1 to an alternating magnetic field with a frequency in the range of 500 Hz to 50 kHz.

13. Method for curing a bone cement paste comprising heating a bone cement paste according to claim 2 by induction until the decomposition of the initiator commences.