Guidewire with adjustable stiffness

• US 9,387,308 B2
• Filed: 03/05/2010
• Issued: 07/12/2016
• Est. Priority Date: 04/23/2007
• Status: Active Grant

• Current Assignee: CardioGuidance Biomedical, LLC
• Original Assignee: CardioGuidance Biomedical, LLC
• Inventors: Hinchliffe, Peter W. J., Freeley, Joseph Martin, Flynn, Cormac, Mooney, Ivan, Lupton, Henry, Parodi, Juan Carlos
• Primary Examiner(s): Stout, Michael C
• Application Number:
  US12/660,891
• Publication Number:
  US 20100305475A1
• Time in Patent Office: 2,321 Days
• Field of Search: 600/585, 604/510
• US Class Current: 1/1
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61M 2025/0006 which can be secured against axial movement, e.g. by using a locking cuff
• CPC Class Codes: A61M 2025/0042 Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 2025/09075 having a core without a coil possibly combined with a sheath
• CPC Class Codes: A61M 2025/09083 having a coil around a core
• CPC Class Codes: A61M 2025/09091 where a sheath surrounds the coil at the distal part
• CPC Class Codes: A61M 2025/09116 Design of handles or shafts or gripping surfaces thereof for manipulating guide wires
• CPC Class Codes: A61M 2025/09133 having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
• CPC Class Codes: A61M 2025/0915 having features for changing the stiffness
• CPC Class Codes: A61M 2025/09175 having specific characteristics at the distal tip
• CPC Class Codes: A61M 25/09 Guide wires
• CPC Class Codes: A61M 25/09025 with sliding mandrils
• CPC Class Codes: A61M 25/09041 Mechanisms for insertion of guide wires
• CPC Class Codes: A61M 25/0905 extendable, e.g. mechanisms for extension
• CPC Class Codes: A61M 5/007 for contrast media

Abstract

A medical guidewire system including an inner member having an outer diameter and an outer member having an inner diameter, the inner diameter being larger than the outer diameter. The inner and outer members are relatively slidable to adjust a stiffness of the guidewire system. The lumen of the outer member forms a gap for fluid flow therethrough. A connector has a first end portion connected to the outer member, a second end portion connected to the inner member and a fluid infusion channel communicating with the gap for injection of fluid through the gap to exit a distal portion of the outer member.

Claims

1. A medical guidewire having adjustable rigidity, comprising:

a first inner wire member having a first outer diameter and a closed distal tip,

a second intermediate wire member having a second outer diameter larger than the first outer diameter, and

a third outer wire member having a third diameter larger than the second outer diameter, the second wire member having a longitudinally extending opening to receive the first wire member for relative sliding movement with respect to the first wire member,

the first wire member movable between a retracted position and an advanced position,

the third outer wire member having a crimped proximal end forming a reduced diameter portion and a longitudinally extending opening to receive the second wire member for relative sliding movement with respect to the first and second wire members,

the second wire member having a flared portion at a distal end thereof to engage the reduced diameter portion of the third wire member for an interlocking frictional engagement, and the first and second wire members have a clamping engagement,

the interlocking frictional engagement and clamping engagement being configured to fix the relative longitudinal position of the first, the second, and the third wire members when the first wire member is in one of the retracted or advanced positions relative to the third wire member,

wherein the first inner wire member, second intermediate wire member and third outer wire member are each independently slidable relative to one another to change the overall diameter, stiffness, and degree of pushability in advancement of the guidewire system, without a need to exchange the system or a portion thereof, and together the members function as a unitary structure such that a proximal region of said guidewire permits a medical device to be longitudinally advanced to a desired location in a patient.

2. The guidewire of claim 1, wherein the first wire member has a first stiffness, the third wire member has a third stiffness greater than the first stiffness, and the second wire member being movable with respect to the third wire member to provide the third wire member with a second stiffness greater than the third stiffness.

3. The guidewire of claim 1, wherein the first wire member comprises a wire having a solid core for at least a majority of its length.

4. The guidewire of claim 1, wherein the first wire member includes a slotted member slidable thereon for selective engagement with the second wire member at a selected position of the first wire member with respect to the second wire member.

5. The guidewire of claim 4, wherein the slotted member has a reduced diameter region with at least one slot extending therethrough.

6. The guidewire of claim 1, wherein the third wire member comprises a hypotube having a series of slots formed in a sidewall to increase flexibility.

7. The guidewire of claim 1, wherein the second wire member comprises a hypotube having a series of slots formed in a sidewall to increase flexibility.

8. The guidewire of claim 6, wherein the space between the slots increases toward a proximal end of the hypotube.

9. The guidewire of claim 1, wherein a proximal end of the third wire member includes a reduced diameter portion engageable by the flared portion of the second wire member.

10. A medical guidewire having adjustable rigidity, comprising:

an inner wire member having an outer diameter and a closed distal tip, and

an outer wire member having an inner diameter larger than the outer diameter, the outer wire member having a longitudinally extending lumen to receive the inner wire member,

the inner wire member movable between a retracted position and an advanced position,

a locking engagement feature being configured to fix the relative longitudinal position of the inner and outer wire members when the inner wire member is in one of the retracted or advanced positions relative to the outer wire member,

the inner wire member and outer wire member being independently slidable relative to one another to change the overall diameter, stiffness, and degree of pushability in advancement of the guidewire, without a need to exchange the guidewire or a portion thereof, and together the members function as a unitary structure such that a proximal region of said guidewire permits a medical device to be longitudinally advanced to a desired location in a patient, the lumen of the outer wire member forming a gap for fluid flow therethrough, the guidewire further having a connector having a first end portion connected to the outer wire member, a second end portion connected to the inner wire member, and a fluid infusion channel communicating with the gap for injection of fluid through the gap to exit a distal portion of the outer wire member.

11. The guidewire of claim 10, wherein the inner wire member is selectively lockable with the outer wire member.

12. The guidewire of claim 10, wherein the gap is defined by an annular space between an outer wall of the inner wire member and an inner wall of the outer wire member.

13. The guidewire of claim 10, wherein the connector includes a first clamping member at the first end portion and a second clamping member at the second end portion.

14. The guidewire of claim 10, wherein the connector includes a rotatable knob at the first end portion to provide a clamping force on the inner wire member.

15. The guidewire of claim 10, wherein the connector includes a rotatable knob at the second end portion to provide a clamping force on the outer wire member.

16. The guidewire of claim 10, wherein the connector includes a side arm for delivering fluid to a lumen of the outer wire member.

17. The guidewire of claim 10, wherein the outer wire member comprises a hypotube having a plurality of slots formed therein.

18. A medical guidewire having adjustable rigidity, comprising:

an inner wire member having an outer diameter and a closed distal tip,

an outer wire member having an inner diameter forming a first lumen, and

an intermediate wire member having a second lumen, the inner diameter being larger than the outer diameter,

the inner wire member movable between a retracted position and an advanced position,

the outer wire member having a longitudinally extending lumen to receive the intermediate wire member,

the lumen of the intermediate wire member forming a gap for fluid flow therethrough,

the guidewire further having a connector having a first end portion connected to the intermediate wire member, a second end portion connected to the inner wire member and a fluid infusion channel communicating with the gap for injection of fluid through the gap to exit a distal portion of the guidewire,

the connector including a first clamping member selectively engageable with a proximal portion of the intermediate wire member and a second clamping member engageable with the inner wire member, and

wherein a looking engagement feature, the first clamping member and the second clamping member being configured to fix the relative longitudinal position of the inner, outer and intermediate wire members when the inner wire member is in one of the retracted or advanced positions relative to the outer wire member,

the inner wire member, intermediate wire member and outer wire member each being independently slidable relative to one another to change the overall diameter, stiffness, and degree of pushability in advancement of the guidewire, without a need to exchange the guidewire or a portion thereof, and together the members function as a unitary structure such that a proximal region of said guidewire permits a medical device to be longitudinally advanced to a desired location in a patient.

19. The medical guidewire of claim 18, wherein the inner wire member has a locking member thereon movable by engagement with the intermediate wire member to a locking position to fix the position of the inner and intermediate wire members, and the intermediate wire member has a flared handle portion frictionally engageable with the outer member to fix the position of the outer and intermediate wire members.