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Process for preparing synthetic prostacyclins

  • US 9,388,154 B2
  • Filed: 09/12/2012
  • Issued: 07/12/2016
  • Est. Priority Date: 09/12/2011
  • Status: Active Grant
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1. A method for preparing a synthetic prostacyclin or a synthetic intermediate thereof, wherein the method comprises contacting an aldehyde with an enantiomerically pure phosphonate in a Horner-Emmons reaction to provide an alkene,wherein the enantiomerically pure phosphonate has a structure:

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