Fluorogenic hydrazine-substituted compounds
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Abstract
The present disclosure is directed to fluorogenic schiff base-forming dyes capable of detecting analytes containing aldehyde and ketone groups. The dyes contain nucleophilic hydrazinyl appendages and are capable of binding and detecting analytes in situ.
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19 Claims
- 1. A hydrazinyl-substituted compound of Formula I:
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11. A compound selected from the group consisting of:
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12. A method for determining the presence of an analyte of interest in a sample, wherein the analyte of interest is selected from the group consisting of an amino acid, a peptide, a protein, a carbohydrate, a polysaccharide, a nucleoside, a nucleotide, an oligonucleotide, a nucleic acid polymer, a drug, a lipid, a synthetic polymer, malondialdehyde, and 4-hydroxynonenal, wherein the method comprises:
contacting the sample with a compound having Formula I; - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
Specification