Cassette assembly for syringe fill system

• US 9,393,177 B2
• Filed: 06/06/2014
• Issued: 07/19/2016
• Est. Priority Date: 08/20/2013
• Status: Active Grant

• Current Assignee: Anutra Medical Inc.
• Original Assignee: Anutra Medical Inc.
• Inventors: Davidian, Daniel K., Newnam, Scott G., Nichols, Eli B., Mosler, Theodore J.
• Primary Examiner(s): Laurenzi, Mark A
• Assistant Examiner(s): SCHMID, ANDREW C
• Application Number:
  US14/298,759
• Publication Number:
  US 20150053306A1
• Time in Patent Office: 774 Days
• Field of Search: 141/2, 141/18, 141/25, 141/27, 141/100, 141/104, 141/105, 141/107, 141/234, 141/235, 141/236, 141/238, 141/290, 141/301, 141/302
• US Class Current: 1/1
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2055 having gripping means
• CPC Class Codes: A61J 1/2075 for external venting
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61J 1/22 with means for metering the amount of fluid
• CPC Class Codes: A61M 2202/048 Anaesthetics see also A61M19/00
• CPC Class Codes: A61M 2205/75 with filters
• CPC Class Codes: A61M 5/001 Apparatus specially adapted for cleaning or sterilising syringes or needles
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: A61M 5/2425 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3137 Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
• CPC Class Codes: A61M 5/31586 performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
• CPC Class Codes: A61M 5/31591 Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/502 for blocking the piston

Abstract

A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for “push-pull”, “pull-push”, “push-push”, and “pull-pull” modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe fillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

Claims

1. A cassette assembly, comprising:

a base manifold member including an elongate interior manifold flow passage;

multiple fluid feed inlets extending outwardly from the base manifold member and communicating with the elongate interior manifold flow passage via inlet passages containing check valves, the multiple inlets being configured for engagement with respective fluid supply containers; and

a syringe coupling mounted on the base manifold member, in fluid flow communication with the interior manifold flow passage to deliver fluid from the interior manifold flow passage to a syringe when coupled to the syringe coupling,

the multiple fluid feed inlets comprising (i) a first fluid feed inlet configured for engagement with a first fluid supply container for dispensing a first fluid to the elongate interior manifold flow passage, and (ii) a second fluid feed inlet configured for engagement with a second fluid supply container for dispensing a second fluid to the elongate interior manifold flow passage, wherein the first fluid supply container is a container from which the first fluid is dispensable by exertion of pressure thereon,

the syringe coupling being in fluid flow communication with the elongate interior manifold flow passage at a first end portion of the elongate interior manifold flow passage,

the second fluid feed inlet being in communication with the elongate interior manifold flow passage at a second end portion of the elongate interior manifold flow passage opposite the first end portion of the elongate interior manifold flow passage,

the first fluid feed inlet being in communication with the elongate interior manifold flow passage at an intermediate portion of the elongate interior manifold flow passage between the first end portion of the elongate interior manifold flow passage and the second end portion of the elongate interior manifold flow passage, and

the cassette assembly being configured for push dispensing of the first fluid from the first fluid supply container through the first fluid feed inlet to the intermediate portion of the elongate interior manifold flow passage, followed by pull dispensing of the second fluid from the second fluid supply container through the second fluid feed inlet to the second end portion of the elongate interior manifold flow passage so that the second fluid intermixes with the first fluid in the elongate manifold fill passage and purges the first fluid from the elongate manifold fill passage during syringe filling.

2. The cassette assembly of claim 1, configured so that there is no introduction of air to the first fluid during dispensing of the first fluid from the first fluid supply container to the intermediate portion of the elongate interior manifold flow passage.

3. The cassette assembly of claim 1, wherein the check valves in the respective inlet passages of the first fluid feed inlet and the second fluid feed inlet have different crack pressures.

4. The cassette assembly of claim 3, wherein the check valve in the inlet passage of the first fluid feed inlet for push dispensing of fluid from the first fluid container has a crack pressure that is in a range of from 6 to 20 psi, and the check valve in the inlet passage of the second fluid feed inlet for pull dispensing of fluid from the second fluid container has a crack pressure that is in a range of from 0.5 to 10 psi, with the proviso that the crack pressure of the check valve in the inlet passage of the first fluid feed inlet for push dispensing is greater than the crack pressure of the check valve in the inlet passage of the second fluid feed inlet for pull dispensing.

5. The cassette assembly of claim 1, comprising a first fluid supply container engaged with the first fluid feed inlet.

6. The cassette assembly of claim 1, comprising a first fluid supply container engaged with the first fluid feed inlet, and a second fluid supply container engaged with the second fluid feed inlet.

7. The cassette assembly of claim 6, wherein the first fluid supply container contains a buffering medium, and the second fluid supply container contains an anesthetic composition.

8. The cassette assembly of claim 7, wherein the buffering medium comprises sodium bicarbonate.

9. The cassette assembly of claim 7, wherein the anesthetic composition comprises lidocaine, articaine, or marcaine.

10. The cassette assembly of claim 1, wherein the multiple fluid feed inlets extend vertically upwardly from a top surface of the base manifold member.

11. The cassette assembly of claim 1, further comprising a second fluid container adapter coupled to the second fluid feed inlet for engagement of a second fluid supply container with the second fluid feed inlet, the second fluid container adapter being adapted to receive a second fluid supply container including a piercable cap or cover.

12. The cassette assembly of claim 11, wherein the second fluid container adapter comprises an air inletting vent enabling air to enter the second fluid supply container to facilitate dispensing of the second fluid therefrom.

13. The cassette assembly of claim 12, wherein the air inletting vent comprises a hydrophobic filter effective to remove airborne contaminants that may adversely affect the second fluid supplied by the second fluid supply container.

14. The cassette assembly of claim 1, wherein the syringe coupling is adapted to be swabable for cleaning and/or sterilization thereof.

15. The cassette assembly of claim 1, adapted as a single-use or disposable assembly.

16. The cassette assembly of claim 15, fabricated predominately of biodegradable plastic and elastomeric material(s) of construction.

17. The cassette assembly of claim 1, comprising a manual gripping element on the base manifold member.

18. The cassette assembly of claim 1, operatively coupled with a syringe fill system comprising a pusher that is adapted to exert pressure on the first fluid supply container for dispensing of the first fluid from the first fluid supply container.

19. A kit, comprising the cassette assembly of claim 1, and at least one of:

(i) one or more fluid supply containers containing fluid, each fluid supply container being adapted for engagement with one of the fluid feed inlets of the base manifold member; and

/or

(ii) one or more syringes, each adapted for engagement with the syringe coupling mounted on the base manifold member.

20. A method of filling a syringe with fluid at a point of use, said method comprising use of the cassette assembly of claim 1, wherein the syringe is coupled with the syringe coupling mounted on the base manifold member of the cassette assembly.