Method and composition for removing uremic toxins in dialysis processes
First Claim
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1. A cartridge for providing regenerative dialysis, the cartridge comprising:
- a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein the zirconium oxide has been modified to remove a nitrate ion and substitute a bicarbonate ion therefor, wherein at least two of the layers are blended together to provide a gradient of the two materials, and the interior being so constructed and arranged that a fluid entering the interior from the inlet flows through a first layer selected from the group consisting of the layer comprising urease and the layer comprising zirconium phosphate, then a second layer selected from the group consisting of the layer comprising urease and the layer comprising zirconium oxide, then a third layer consisting of the layer comprising zirconium phosphate, and then a fourth layer consisting of the layer comprising zirconium oxide.
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Abstract
Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.
21 Citations
19 Claims
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1. A cartridge for providing regenerative dialysis, the cartridge comprising:
a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein the zirconium oxide has been modified to remove a nitrate ion and substitute a bicarbonate ion therefor, wherein at least two of the layers are blended together to provide a gradient of the two materials, and the interior being so constructed and arranged that a fluid entering the interior from the inlet flows through a first layer selected from the group consisting of the layer comprising urease and the layer comprising zirconium phosphate, then a second layer selected from the group consisting of the layer comprising urease and the layer comprising zirconium oxide, then a third layer consisting of the layer comprising zirconium phosphate, and then a fourth layer consisting of the layer comprising zirconium oxide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A cartridge for providing regenerative dialysis, the cartridge comprising:
a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising carbon, and a blended layer comprising zirconium oxide and zirconium phosphate, wherein the zirconium oxide has been modified to remove a nitrate ion and substitute a bicarbonate ion therefor, and wherein at least two of the layers are blended together to provide a gradient of the two materials. - View Dependent Claims (11, 12)
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13. A device for removing uremic toxins in a dialysis procedure, the device comprising:
a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein the zirconium oxide has been modified to remove a nitrate ion and substitute a bicarbonate ion therefor, wherein at least two of the layers are blended together to provide a gradient of the two materials, and the device being constructed and arranged so that a fluid entering the device contacts an initial layer comprising at least the layer comprising zirconium oxide upon entering the device before contacting any other layer. - View Dependent Claims (14, 15)
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16. A device for regenerating a dialysis solution, the device comprising:
a body defining an interior, the interior including at least a layer of urease, zirconium phosphate, zirconium oxide, and carbon, wherein the zirconium oxide has been modified to remove a nitrate ion and substitute a bicarbonate ion therefor, wherein at least two of the layers are blended together to provide a gradient of the two materials, and the device being so constructed and arranged that a dialysis solution having a pH that is either basic or acidic entering a resin bed will exit the resin bed at a pH of approximately 7 to about 7.8. - View Dependent Claims (17, 18)
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19. A cartridge for providing regenerative dialysis, the cartridge comprising:
a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein the zirconium oxide has been modified to remove a nitrate ion and substitute a bicarbonate ion therefor, and wherein at least two of the layers are blended together to provide a gradient of the two materials.
Specification