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Prefilled syringes and kits thereof

  • US 9,393,367 B2
  • Filed: 04/03/2015
  • Issued: 07/19/2016
  • Est. Priority Date: 03/12/2013
  • Status: Active Grant
First Claim
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1. A medical kit comprising:

  • a first kit comprising at least two prefilled syringes configured to deliver methotrexate subcutaneously to a patient in need thereof and instructions for the use of the syringes,wherein the prefilled syringes of the first kit include a pharmaceutical composition comprising a dose of methotrexate in a volume of a pharmaceutically acceptable solvent that includes water or ethanol,wherein the dose of methotrexate is in a range of from about 7.5 mg to about 25 mg,wherein the volume of the pharmaceutical composition in the prefilled syringes of the first kit is greater than 0.01 ml but less than or equal to 1 ml and the concentration of the methotrexate in the prefilled syringes is 25 mg/ml, andwherein the first kit does not include an autoinjector, anda second kit comprising at least two prefilled syringes configured to deliver methotrexate subcutaneously to a patient in need thereof and instructions for the use of the syringes,wherein the prefilled syringes of the second kit include a pharmaceutical composition comprising a dose of methotrexate in a volume of a pharmaceutically acceptable solvent that includes water or ethanol,wherein the dose of methotrexate is in a range of from about 7.5 mg to about 25 mg,wherein the volume of the pharmaceutical composition in the prefilled syringes of the second kit is greater than 0.01 ml but less than or equal to 1ml and the concentration of the methotrexate in the prefilled syringes is 25 mg/ml,wherein the second kit does not include an autoinjector, andwherein the volume of the prefilled syringes of the second kit is different than the volume of the prefilled syringes of the first kit.

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