Apparatuses and methods for cooling specific tissue

• US 9,393,378 B2
• Filed: 09/12/2012
• Issued: 07/19/2016
• Est. Priority Date: 03/15/2010
• Status: Active Grant

• Current Assignee: Muffin Incorporated
• Original Assignee: Muffin Incorporated
• Inventors: Nielsen, Jesper Thyregod, Fearnot, Neal E.
• Primary Examiner(s): Woodward, Valerie L
• Application Number:
  US13/610,930
• Publication Number:
  US 20130000642A1
• Time in Patent Office: 1,406 Days
• Field of Search: 128/205.22, 128/204.15
• US Class Current: 1/1
• CPC Class Codes: A61F 2007/0002 Head or parts thereof
• CPC Class Codes: A61F 2007/0006 Nose
• CPC Class Codes: A61F 2007/0063 for cooling
• CPC Class Codes: A61F 2007/0064 of gas
• CPC Class Codes: A61F 2007/0096 with a thermometer
• CPC Class Codes: A61F 2007/0228 with belt or strap, e.g. with buckle
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61M 16/0461 Nasoendotracheal tubes
• CPC Class Codes: A61M 16/0493 with means for protecting the tube from damage caused by the patient's teeth, e.g. bite block
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/0683 Holding devices therefor
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 19/00 Local anaesthesia syringes therefor A61M5/00; Hypothermia A61M5/42 takes precedence; cooling blood in a bypass of the arterial system A61M1/36
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3606 cooled
• CPC Class Codes: A61M 2205/362 by gas flow
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum

Abstract

Among other things, there is provided a system for providing therapeutic cooling or hypothermia to localized areas of the body such as the brain. A source of compressed gas such as a medical-use oxygen canister is connected via a delivery tube to a mask fitted to a patient. The gas undergoes adiabatic cooling as it enters the delivery tube, and is provide to the patient in such cooled state. The system may be provided as a portable or ambulatory device or kit, with the delivery tube or other part easily disconnected from one compressed gas source and connected to another, for continued therapy even during transportation.

Claims

1. A system for therapeutic cooling of a patient, comprising:

a mask having a strap and a hole, said mask being adapted to cover at least the patient'"'"'s nose and to be held to the patient'"'"'s head by said strap, so that when said mask rests against the patient'"'"'s face a space between at least a portion of the patient'"'"'s face and said mask exists;

a source of coolant, said coolant consisting essentially of compressed breathable gas, wherein a flow path extends from said source through said hole of said mask;

a regulator in said flow path between said coolant source and said hole of said mask; and

a delivery tube having a lumen defining at least part of said flow path for said coolant, for conducting said coolant toward said mask;

wherein said coolant is cooled adiabatically on or after release from said source, and wherein first and second insertion tubes are connected to said delivery tube, each extending to a respective free end having an opening, said insertion tubes sized and configured to be inserted into respective nares of a patient'"'"'s nose so that said free ends are positioned in the airway beyond the anterior turbinate area of the patient'"'"'s nose, so that the gas passes the mucosa and conchae of the nose before exiting said insertion tubes,

wherein at least one of said delivery tube and at least one insertion tube extend through said hole of said mask so that said mask rests against the patient'"'"'s face when said at least one insertion tube is inserted into the patient'"'"'s nose.

2. The system of claim 1, wherein said source is a canister of compressed breathable gas.

3. The system of claim 1, wherein a configuration of said delivery tube includes forming said delivery tube of foam insulation.

4. The system of claim 1, wherein a configuration of said delivery tube includes forming said delivery tube of an internal plastic lumen with an outer layer of foam insulation.

5. The system of claim 1, wherein said source includes two compressed gas canisters, and further comprising a Y-shaped connector connected to said delivery tube and to each of said canisters.

6. The system of claim 1, wherein said source includes two compressed gas canisters, and further comprising a two-way stopcock connected to each of said canisters and to said delivery tube.

7. The system of claim 1, wherein said regulator is fixed to said mask so that an output of said regulator communicates with said hole of said mask, so that adiabatically-cooled gas from said regulator enters said mask.

8. The system of claim 1, wherein said delivery tube is a high-pressure tube from said source to said regulator.

9. The system of claim 1, wherein said mask is adapted to cover the eyes of a patient.

10. The system of claim 1, wherein said mask is a full-face mask.

11. The system of claim 1, wherein said mask is adapted to cover the mouth of the patient.

12. The system of claim 1, further comprising a sensor connected to one or more of said delivery tube, regulator and mask, and a readout communicatively connected to said sensor, said readout providing an indication of at least one of temperature and pressure of said coolant.

13. The system of claim 12, wherein said readout is fixed to said mask and said mask permits observation of the patient'"'"'s eyes when fitted to the patient, and wherein the patient'"'"'s eyes and said readout are both within an observer'"'"'s field of vision when said mask is fitted to the patient.

14. A system for cooling the brain with compressed gas, comprising:

a supply of a compressed breathable gas for thermal transfer with tissues in a patient'"'"'s head, said gas provided in at least one canister initially at a first pressure greater than atmospheric pressure;

a mask for fitting over a patient'"'"'s face to cover at least the patient'"'"'s nose and eyes, said mask having a regulator fitted thereto;

a high-pressure delivery tube connecting said at least one canister with said regulator, said delivery tube configured such that gas traveling along said delivery tube remains at approximately the same temperature along said tube,

wherein said gas is cooled adiabatically to a first temperature below room temperature, and said gas flows into said mask at approximately the first temperature to cool tissues adjacent the brain cavity, and wherein a set of first and second nasal tubes is at least partially within said mask, each said nasal tube for insertion into a respective nostril of a patient, said first and second nasal tubes each having a respective distal end with a respective hole, and each being sized and configured so that when said first and second nasal tubes are fully inserted into the patient, said respective distal ends are positioned in one or more of the choanae of the patient, without closing an airway through either nostril.

15. The system of claim 14, wherein said first temperature is between 0 and 20 degrees Celsius.

16. The system of claim 14, wherein said supply of breathable gas is sufficient in flow, temperature and duration to cool at least a portion of the brain by about 1 to 5 Celsius degrees.

17. The system of claim 14, wherein said supply is provided by multiple canisters of compressed gas, and wherein said delivery tube is adapted to easily accept flow from multiple canisters.

18. The system of claim 14, wherein said delivery tube is connected to a stopcock, and said stopcock is connected to said multiple canisters of compressed gas, wherein said stopcock is operable to switch flow into said delivery tube between or among said multiple canisters.

19. The system of claim 14, wherein a configuration of said delivery tube includes a layer of insulation incorporated in or on said delivery tube.

20. The system of claim 14, further comprising at least one sensor for detecting at least one of a flow rate in said delivery tube and a temperature of said gas, and at least one readout communicatively connected to said at least one sensor for displaying information derived from said sensor to an external observer, wherein said readout is fixed to said mask.

21. A cooling system for applying localized hypothermic treatment, comprising:

a heat-transfer medium consisting essentially of a breathable gas, said gas supplied in at least one canister at a pressure greater than atmospheric pressure;

a delivery tube connected to said canister, said delivery tube configured so that said gas can travel along said delivery tube without a significant change in temperature of said gas along said length;

a mask having a regulator connected to said delivery tube so that output of said regulator flows into said mask, said mask further having a readout display attached thereto, said readout display showing information related to the operation of the system;

a stopcock connected to said delivery tube, said stopcock being operable to change flow into said delivery tube from a first said canister to a second said canister; and

a pair of insertion tubes connected to said delivery tube and sized and configured so that respective distal ends of each of said insertion tubes are in the choanae of the patient when said insertion tubes are fully inserted into the patient, wherein said insertion tubes each have a single outlet at said respective distal ends of said insertion tubes, whereby said gas exits said tubes in one direction.

22. The system of claim 21, wherein said canister is of a hand-portable size and weight, so that said system is carryable to a patient by an emergency responder.

23. The system of claim 21, wherein a configuration of said delivery tube includes said delivery tube being formed entirely of a foam insulation.