Systems and methods for using electrical impedance for neuro cardiac therapy

• US 9,393,415 B2
• Filed: 12/01/2011
• Issued: 07/19/2016
• Est. Priority Date: 12/29/2010
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Arcot-Krishnamurthy, Shantha, Zhang, Yi, Hatlestad, John D.
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): Ramachandran, Vasuda
• Application Number:
  US13/309,320
• Publication Number:
  US 20120172742A1
• Time in Patent Office: 1,692 Days
• Field of Search: 600/536
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/3614 based on impedance measurement
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.

Claims

1. A method, comprising:

delivering, using a neural stimulator, a vagal stimulation therapy (VST) to a vagus nerve of a patient, wherein delivering the VST includes delivering a therapeutically-effective intensity of neural stimulation to treat a condition, wherein the therapeutically-effective intensity of neural stimulation causes laryngeal vibrations;

performing a stimulation capture confirmation process multiple times and intermittently during delivery of the VST, wherein performing the stimulation capture confirmation process includes detecting laryngeal vibrations to determine whether the VST is capturing the vagus nerve, wherein detecting laryngeal vibrations includes;

sensing impedance in a cervical region of a patient to sense changes in impedance characteristics caused by laryngeal vibrations, wherein sensing impedance includes sensing impedance a plurality of times to provide a plurality of sensed impedance values;

detecting laryngeal vibrations when the VST does not cause cough, including analyzing a plurality of the sensed impedance values to determine whether the VST causes laryngeal vibrations, including whether the VST causes laryngeal vibrations when the VST does not cause cough, and thereby determine whether the VST is capturing the vagus nerve; and

detecting cough, including analyzing a plurality of the sensed impedance values to determine whether the VST causes cough; and

maintaining the therapeutically-effective intensity of the neural stimulation for the VST during the stimulation capture confirmation process, including controlling the intensity based on the sensed impedance values to maintain capture of the vagus nerve and avoid cough.

2. The method of claim 1, wherein delivering the VST includes delivering the VST using an electrode in a blood vessel;

and sensing impedance includes sensing impedance using the electrode in the blood vessel.

3. The method of claim 2, wherein the blood vessel is an internal jugular vein.

4. The method of claim 1, wherein delivering VST includes delivering a neuro cardio therapy (NCT) to treat a cardiovascular disease, wherein delivering NCT includes delivering NCT as a heart failure therapy or delivering NCT as a hypertension therapy.

5. The method of claim 1, wherein analyzing the plurality of the sensed impedance values includes detecting a change in absolute impedance values, detecting a change in mean of the sensed impedance values, or detecting a change in variability of the sensed impedance values.

6. The method of claim 5, wherein analyzing the plurality of the sensed impedance values includes analyzing the variability of the plurality of the sensed impedance, and analyzing the variability of the plurality of the sensed impedance includes determining a standard deviation or an Inter-Percentile Range of the sensed impedance.

7. A method for detecting laryngeal vibrations and cough and controlling a vagal stimulation therapy (VST) delivered using a neural stimulator to cause laryngeal vibrations and avoid cough, comprising:

delivering VST, wherein the VST includes a therapeutically-effective intensity of neural stimulation to treat a condition, and the therapeutically-effective intensity of neural stimulation causes laryngeal vibrations; and

performing a stimulation capture confirmation process multiple times and intermittently during delivery of the VST, wherein the stimulation capture confirmation process includes;

sensing impedance in a cervical region of a patient to sense changes in impedance characteristics caused by laryngeal vibrations when cough is not present and caused by laryngeal vibrations when cough is present, wherein sensing impedance includes sensing impedance a plurality of times to provide the plurality of sensed impedance values; and

analyzing a plurality of the sensed impedance values to identify the laryngeal vibrations and identify the cough, wherein sensing impedance includes;

sensing impedance changes in or near a carotid sheath;

or

sensing impedance using a lead in an internal jugular vein; and

controlling an intensity of the VST delivered using the neural stimulator based on the sensed impedance to maintain the therapeutically-effective intensity of the neural stimulation for VST during the stimulation capture confirmation process that causes laryngeal vibrations and avoids cough.