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Movement disorder therapy system, devices and methods of tuning

  • US 9,393,418 B2
  • Filed: 04/12/2013
  • Issued: 07/19/2016
  • Est. Priority Date: 06/03/2011
  • Status: Active Grant
First Claim
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1. A method of tuning a movement disorder therapy system comprising steps of:

  • providing a movement disorder diagnostic device to a subject with an implanted deep brain stimulation (DBS) device operable according to adjustable DBS parameters,wherein the movement disorder diagnostic device comprises at least one physiological or movement sensor capable of generating a signal, and the DBS parameters include one or more of stimulation frequency, amplitude, pulse width, pulse wavelength, waveform type, and contact configuration;

    supplying, by the DBS device, a stimulation current to the subject'"'"'s brain under a set of first level DBS parameters;

    instructing the subject to perform a first movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy,wherein the first movement disorder test corresponds to the set of first level DBS parameters of the DBS therapy;

    measuring, by the movement disorder diagnostic device, symptomatic movement of the subject to obtain movement data based at least in part on the generated signal from the at least one physiological or movement sensor during the first movement disorder test;

    supplying, by the DBS device, a stimulation current to the subject'"'"'s brain under a set of second level DBS parameters;

    instructing the subject to perform a second movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy, wherein the second movement disorder test corresponds to the set of second level DBS parameters of the DBS therapy;

    measuring, by the movement disorder diagnostic device, symptomatic movement of the subject to obtain movement data based at least in part on the generated signal from the at least one physiological or movement sensor during the second movement disorder test;

    transmitting, by the movement disorder diagnostic device, the measured movement data to a processor;

    quantifying, by the processor, the subject'"'"'s motor symptoms based on the measured movement data;

    combining, by the processor, data corresponding to the subject'"'"'s measured and quantified motor symptoms from the first movement disorder test, data corresponding to at least two test parameters from the first movement disorder test, data corresponding to the subject'"'"'s measured and quantified motor symptoms from the second movement disorder test, and data corresponding to the set of second level DBS parameters;

    generating, by the processor, based on the combined data, a tuning map comprising a two-dimensional representation of a three-dimensional graph that illustrates a correlation between the test parameters and the data corresponding to the subject'"'"'s measured and quantified motor symptoms;

    displaying, on a display or in a report, the generated tuning map for viewing by a clinician, technician or physician;

    determining, by the clinician, technician or physician, based at least in part on the tuning map, a set of new level DBS parameters to alter the subject'"'"'s performance on at least one movement disorder test;

    entering, automatically by the device with a processor or manually by the clinician, technician or physician, the set of new level DBS parameters into a programmer device in communication with the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the set of new level DBS parameters; and

    supplying, by the DBS device, a stimulation current to the subject'"'"'s brain under the set of new level DBS parameters to provide altered DBS therapy to the subject.

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