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Methods for preparing purified polypeptide compositions

  • US 9,394,336 B2
  • Filed: 01/13/2012
  • Issued: 07/19/2016
  • Est. Priority Date: 09/22/2008
  • Status: Active Grant
First Claim
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1. A pharmaceutically acceptable composition comprising:

  • a peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof comprising an alpha-helix and a cross-linker connecting a first amino acid and a second amino acid, the cross-linker spanning from 1 turn to 5 turns of the alpha-helix; and

    a metal residue, from a metathesis catalyst, at a concentration of from about 0.5 ppm to about 10 ppm by weight as measured by nuclear inductively coupled plasma analysis (ICP) or nuclear inductively coupled plasma mass spectrometry analysis (ICP-ms);

    wherein the pharmaceutically acceptable composition is suitable for administration to a human subject,and wherein the peptidomimetic macrocycle or the pharmaceutically acceptable salt is of Formula (I);

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