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Human monoclonal antibodies specific for glypican-3 and use thereof

  • US 9,394,364 B2
  • Filed: 08/27/2015
  • Issued: 07/19/2016
  • Est. Priority Date: 04/19/2011
  • Status: Active Grant
First Claim
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1. An isolated human monoclonal antibody that binds heparan sulfate (HS) on glypican-3 (GPC3), wherein:

  • (i) the heavy chain of the antibody comprises amino acid residues 26-33, 51-58 and 97-105 of SEQ ID NO;

    14; and

    (ii) the light chain of the antibody comprises amino acid residues 27-32, 50-52 and 89-97 of SEQ ID NO;

    16 or amino acid residues 27-32, 50-52 and 89-97 of SEQ ID NO;

    31.

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