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Compositions for linking DNA-binding domains and cleavage domains

  • US 9,394,531 B2
  • Filed: 05/28/2009
  • Issued: 07/19/2016
  • Est. Priority Date: 05/28/2008
  • Status: Active Grant
First Claim
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1. A fusion protein comprising from N-terminus to C-terminus:

  • a DNA-binding domain that binds to a nucleotide target site;

    a ZC linker (SEQ ID NO;

    2); and

    a FokI cleavage domain, wherein the FokI cleavage domain comprises the sequence shown in residues 158 to 356 of SEQ ID NO;

    3 or residues 158 to 360 of SEQ ID NO;

    4.

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