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Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG

  • US 9,394,542 B2
  • Filed: 01/22/2015
  • Issued: 07/19/2016
  • Est. Priority Date: 07/14/2010
  • Status: Expired due to Fees
First Claim
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1. A synthetic, modified oligonucleotide of 14 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from:

  • at least one modified sugar moiety;

    at least one modified internucleotide linkage;

    at least one modified nucleotide, and combinations thereof;

    wherein said oligonucleotide is an antisense compound which specifically hybridizes and shares 100% complementarity over the full length to a natural antisense polynucleotide of a Discs large homolog 1 (DLG1) gene and upregulates the function and/or expression of a Discs large homolog 1 (DLG1) gene in vivo or in vitro as compared to a normal control, and wherein said modified oligonucleotide is not a primer or probe.

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