Method and device for optical imaging of a turbid medium
First Claim
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1. A method for optical imaging of a turbid medium present in a human subject, the method comprising:
- measuring reference intensities of light emanating from the turbid medium while an O2/N2 gas mixture is supplied to the human subject and while the O2/N2 gas mixture has a reference ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2);
reconstructing a reference image of the turbid medium from the measured reference intensities;
measuring contrast intensities of the light emanating from the turbid medium while the O2/N2 gas mixture is supplied to the human subject and while the O2/N2 gas mixture has a contrast ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2);
reconstructing a contrast image of the turbid medium from the measured contrast intensities; and
comparing the contrast image of the turbid medium to the reference image of the turbid medium,wherein the reference ratio is different from the contrast ratio.
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Abstract
Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
6 Citations
10 Claims
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1. A method for optical imaging of a turbid medium present in a human subject, the method comprising:
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measuring reference intensities of light emanating from the turbid medium while an O2/N2 gas mixture is supplied to the human subject and while the O2/N2 gas mixture has a reference ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2); reconstructing a reference image of the turbid medium from the measured reference intensities; measuring contrast intensities of the light emanating from the turbid medium while the O2/N2 gas mixture is supplied to the human subject and while the O2/N2 gas mixture has a contrast ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2); reconstructing a contrast image of the turbid medium from the measured contrast intensities; and comparing the contrast image of the turbid medium to the reference image of the turbid medium, wherein the reference ratio is different from the contrast ratio. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An apparatus for optical imaging of a turbid medium present in a human subject, the apparatus comprising:
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an O2/N2-modulator configured to supply an O2/N2 gas mixture to the human subject and to modulate a ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2) in the O2/N2 gas mixture; one or more detector modules configured to detect light emanating from the turbid medium when the O2/N2-modulator causes the O2/N2 gas mixture to have a reference ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2), and to detect light emanating from the turbid medium when the O2/N2-modulator causes the O2/N2 gas mixture to have a contrast ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2), wherein the reference ratio is different than the contrast ratio; a processor configured to reconstruct a reference image from an output of the one or more detector modules when the O2/N2 gas mixture has the reference ratio, and to reconstruct a contrast image from an output of the one or more detector modules when the O2/N2 gas mixture has the contrast ratio; and a comparator module configured to carry-out a comparison between the contrast and reference images. - View Dependent Claims (9)
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10. A tangible non-transitory data carrier having stored thereon computer programming instructions for causing a processor to execute an algorithm, comprising:
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measuring reference intensities of light emanating from the turbid medium of a human subject while an O2/N2 gas mixture is supplied to the human subject and while the O2/N2 gas mixture has a reference ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2); reconstructing a reference image of the turbid medium from the measured reference intensities; measuring contrast intensities of the light emanating from the turbid medium while the O2/N2 gas mixture is supplied to the human subject and while the O2/N2 gas mixture has a contrast ratio of partial oxygen pressure (pO2) to partial nitrogen pressure (pN2); and reconstructing a contrast image of the turbid medium from the measured contrast intensities, and comparing the contrast image of the turbid medium to the reference image of the turbid medium, wherein the reference ratio is different from the contrast ratio.
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Current AssigneeKoninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
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Original AssigneeKoninklijke Philips N.V.
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InventorsVan Der Mark, Martinus Bernardus, Van Beek, Michael Cornelis, Bakker, Levinus Pieter
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Primary Examiner(s)Le, Long V
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Assistant Examiner(s)BOR, HELENE CATHERINE
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Application NumberUS12/094,670Publication NumberTime in Patent Office3,539 DaysField of Search600/475, 600/477, 600/479, 600/310, 424/9.1US Class Current1/1CPC Class CodesA61B 5/0091 for mammographyA61B 5/1455 using optical sensors, e.g....A61B 5/14551 for measuring blood gasesA61B 5/4312 Breast evaluation or disord...
