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Detecting neoplasm

  • US 9,399,800 B2
  • Filed: 08/14/2015
  • Issued: 07/26/2016
  • Est. Priority Date: 02/15/2008
  • Status: Active Grant
First Claim
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1. A system for detecting colorectal cancer or pre-cancer in a mammal, said system comprising:

  • a) a stool sample,b) reagents sufficient for measuring a K-ras mutation score within said stool sample, wherein said reagents comprise K-ras specific primers, andc) reagents sufficient for converting unmethylated cytosine residues to uracil residues within said stool sample while leaving 5-methylcytosine residues unchanged, wherein said reagents sufficient for converting unmethylated cytosine residues to uracil residues within said stool sample while leaving 5-methylcytosine residues unchanged comprise a bisulfite reagent, and reagents sufficient for measuring BMP3 methylation within said stool sample, wherein said reagents sufficient for measuring BMP3 methylation comprise BMP3 specific primers and a bisulfite reagent.

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