Dynamic bioactive nanofiber scaffolding

• US 9,402,724 B2
• Filed: 12/20/2012
• Issued: 08/02/2016
• Est. Priority Date: 05/12/2008
• Status: Active Grant

• Current Assignee: MO-SCI Corporation (Heraeus Holding GMBH)
• Original Assignee: MO-SCI Corporation (Heraeus Holding GMBH)
• Inventors: Day, Thomas E., Jung, Steven B., Bagga, Charanpreet S.
• Primary Examiner(s): Sharma, Yashita
• Application Number:
  US13/721,724
• Publication Number:
  US 20140180434A1
• Time in Patent Office: 1,321 Days
• Field of Search: 623 2347- 2363, 623 2372- 2376, 424422-426, 424/445, 424/601, 424/618, 424/630, 424/639, 424/642, 424/646, 424/657, 424/673, 427 224- 227
• US Class Current: 1/1
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/10 Ceramics or glasses
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/427 of other specific inorganic materials not covered by A61L27/422 or A61L27/425
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

Claims

1. A resorbable bone graft scaffold material, comprising:

a plurality of overlapping and interlinking nonporous, polymer-free bioactive ceramic fibers defining a scaffold structure;

a plurality of pores distributed throughout and defined by the scaffold; and

a first plurality of first bioactive, resorbable spheres distributed in at least some of the respective pores;

wherein each respective first sphere is fused to at least one ceramic fiber;

a second plurality of second loose bioactive, resorbable spheres, wherein each respective second loose sphere is not fused to a fiber;

wherein the fibers are characterized by fiber diameters ranging from 5 nanometers to 100 micrometers;

wherein the fibers are composed of a bioactive, resorbable material.

2. The resorbable bone graft scaffold material of claim 1 wherein the fibers are composed of a material selected from the group including calcium phosphate, hydroxyapatite, bioactive glass and combinations thereof.

3. The resorbable bone graft scaffold material of claim 1 wherein the fibers are composed of 45S5 bioactive glass.

4. The resorbable bone graft scaffold material of claim 1 wherein the first spheres are solid and have the same composition as the fibers.

5. The resorbable bone graft scaffold material of claim 1 wherein the first spheres are hollow defining respective inner core volumes;

and wherein each respective inner core volume is filled with a filling selected from the group including medicines, nutritive supplements, antibiotics, antivirals, vitamins and combinations thereof.

6. The resorbable bone graft scaffold material of claim 1 wherein the fiber diameters are substantially between 10 nanometers and 10 micrometers.

7. The resorbable bone graft scaffold material of claim 1 wherein the fiber diameters are substantially between 1 micrometer and 10 micrometers.

8. The resorbable bone graft scaffold material of claim 1 wherein the fiber diameters are substantially less than 400 nanometers.

9. The resorbable bone graft scaffold material of claim 1 wherein the plurality of overlapping and interlinking fibers are at least partially fused together.

10. The resorbable bone graft scaffold material of claim 1 wherein the spheres have diameters ranging from 30 microns to 3 millimeters.