Multifunctional small molecules
First Claim
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1. A composition comprising a generation 5 or higher PAMAM dendrimer conjugated with one or more cyclooctyne moieties.
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Abstract
The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of use of the same.
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Citations
12 Claims
- 1. A composition comprising a generation 5 or higher PAMAM dendrimer conjugated with one or more cyclooctyne moieties.
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9. A method of synthesizing a functionalized dendrimer, said method comprising:
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a) providing a generation 5 or higher PAMAM dendrimer having one or more cyclooctyne moieties and a one or more ligands having an azide moiety; and b) conjugating said generation 5 or higher PAMAM dendrimer with said ligands via copper-free click chemistry between said cyclooctyne moiety and said azide moiety. - View Dependent Claims (10, 11, 12)
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Specification