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Enhanced clearance in an artificial kidney incorporating a pulsatile pump

  • US 9,402,941 B2
  • Filed: 01/10/2014
  • Issued: 08/02/2016
  • Est. Priority Date: 11/16/2001
  • Status: Expired due to Term
First Claim
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1. A method of dialysis comprising:

  • receiving blood in a blood circuit of a dialysis device;

    pumping the blood in a pulsed manner to provide an average pulsatile blood flow rate of between 30 and 90 ml/min;

    pumping dialysate, in a dialysate circuit of said dialysis device, in a pulsed manner to provide an average pulsatile dialysate flow rate of between 30 and 90 ml/min;

    receiving said pumped blood at a blood inlet of a dialyzer; and

    receiving said pumped dialysate at a dialysate inlet of said dialyzer, wherein a pressure differential between said blood in said blood inlet and said dialysate in said dialysate inlet fluctuates at a periodic rate between 0 mmHg+/−

    10 mmHg and 120 mmHg+/−

    20 mmHg; and

    transferring urea molecules from said blood to said dialysate while said blood and said dialysate are passing through said dialyzer;

    cleaning said dialysate by a filtration means, said cleaned dialysate being recirculated in said dialysate circuit.

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