Minimally invasive lung volume reduction devices, methods, and systems

• US 9,402,971 B2
• Filed: 01/23/2014
• Issued: 08/02/2016
• Est. Priority Date: 03/13/2006
• Status: Active Grant

• Current Assignee: Ekos LLC (Boston Scientific Corporation)
• Original Assignee: PneumRx, Inc. (Boston Scientific Corporation)
• Inventors: Mathis, Mark L.
• Primary Examiner(s): ANDERSON, GREGORY A
• Application Number:
  US14/162,124
• Publication Number:
  US 20140371705A1
• Time in Patent Office: 922 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 1/044 for absorption imaging
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12131 characterised by the type of occluding device
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/00477 Coupling A61B2017/0046 takes precedence
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/485 involving fluorescence X-ray imaging
• CPC Class Codes: A61B 90/00 Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges protective face masks A41D13/11; surgeon's or patient's gowns or dresses A41D13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M1/00
• CPC Class Codes: A61B 90/02 Devices for expanding tissue, e.g. skin tissue implements for holding wounds open, surgical tractors A61B17/02; implantable mammary prosthesis A61F2/12; dilators A61M29/00
• CPC Class Codes: A61F 2002/043 : Bronchi
• CPC Class Codes: A61F 2002/046 : Tracheae
• CPC Class Codes: A61M 16/04 : Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0406 : implanted flow modifiers
• CPC Class Codes: A61M 16/0833 : T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 16/208 : Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2205/0266 : Shape memory materials
• CPC Class Codes: A61M 2205/32 : with radio-opaque indicia
• CPC Class Codes: A61M 37/0069 : Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.

Claims

1. An implant for deployment within an airway of a lung of a patient for treating the lung of the patient, the implant comprising:

a first portion having a first bearing surface and defining a first local axis, the first portion of the implant configured to engage a first portion of the airway with the first bearing surface; and

the implant further comprising a second portion coupled to the first portion of the implant, the second portion of the implant having a second bearing surface and defining a second local axis, the second portion of the implant configured to engage a second portion of the airway with the second bearing surface, the second portion of the airway being axially spaced apart from the first portion of the airway;

wherein, in a deployed configuration within the lung, the first portion of the implant presses against the first portion of the airway in a direction lateral to the first local axis and toward the second portion of the implant, and the second portion of the implant presses against the second portion of the airway in a direction lateral to the second local axis and toward the first portion of the implant, thereby compressing lung tissue between the first and second portions of the implant.

2. The implant of claim 1, further comprising a third portion having a third bearing surface and defining a third local axis, the third portion configured to engage the airway with the third bearing surface;

and in the deployed configuration within the lung, the third portion presses against the airway in a direction lateral to the third local axis and toward the first portion of the implant and the second portion of the implant, thereby compressing lung tissue between the first, second, and third portions of the implant.

3. The implant of claim 2, further comprising a fourth portion having a fourth bearing surface and defining a fourth local axis, the fourth portion configured to engage the airway with the fourth bearing surface;

and in the deployed configuration within the lung, the fourth portion presses against the airway in a direction lateral to the fourth local axis and toward the first, second, and third portions of the implant, thereby compressing lung tissue between the first, second, third, fourth portions of the implant.

4. The implant of claim 3, wherein the first, second, third, and fourth local axes are parallel to each other.

5. The implant of claim 1, further comprising an anchor for anchoring the implant within the airway of the lung.

6. The implant of claim 1, wherein the implant is loaded with a therapeutic drug for release during implant deployment within the airway of the lung.

7. The implant of claim 6, wherein the implant comprises a polymer material and wherein the polymer material regulates a release of the therapeutic drug.

8. The implant of claim 7, wherein the therapeutic drug reduces the rate of wound healing, tissue remodeling, inflammation, generation of granular tissue or a combination of these.

9. An implant for deployment within an airway of a lung of a patient for treating the lung of the patient, the implant comprising:

an elongate body having a proximal end and a distal end;

the elongate body configured to transition between a delivery configuration and a deployed configuration; and

wherein the deployed configuration of the elongate body exerts force on the airway to fold a first portion of the airway of the lung toward a second portion of the airway that is axially spaced apart from the first portion of the airway for locally compressing the lung; and

wherein the elongate body is configured to elute a therapeutic drug.

10. The implant of claim 9, wherein the therapeutic drug is configured to locally reduce a wound healing rate.

11. The implant of claim 9, wherein the therapeutic drug is configured to locally reduce tissue remodeling.

12. The implant of claim 9, wherein the therapeutic drug is configured to locally reduce inflammation.

13. The implant of claim 9, wherein the therapeutic drug is configured to reduce granular tissue formation.

14. The implant of claim 9, wherein the therapeutic drug is configured to reduce hyperplasia.

15. The implant of claim 9, wherein the elongate body comprises a polymer material and wherein the polymer material regulates a release of the therapeutic drug.

16. A method for treating a patient having a lung with an airway, the method comprising:

deploying a lung implant to the airway of the lung, the implant comprising an elongate body having a proximal end and a distal end;

wherein the elongate body of the deployed lung implant folds a first portion of the airway of the lung toward a second portion of the airway that is axially spaced apart from the first portion of the airway; and

wherein the elongate body of the lung implant is configured to elute a therapeutic drug.

17. The method of claim 16, wherein the therapeutic drug released by the elongate body is configured to locally reduce a wound healing rate.

18. The method of claim 16, wherein the therapeutic drug released by the elongate body is configured to locally reduce tissue remodeling.

19. The method of claim 16, wherein the therapeutic drug released by the elongate body is configured to locally reduce inflammation.

20. The method of claim 16, wherein the therapeutic drug released by the elongate body is configured to reduce granular tissue formation.

21. The method of claim 16, wherein the therapeutic drug released by the elongate body is configured to reduce hyperplasia.

22. The method of claim 16, wherein the elongate body of the lung implant comprises a polymer material and wherein the polymer material regulates a release of the therapeutic drug.