Methods and apparatus for multi-vessel renal neuromodulation
First Claim
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1. An apparatus for performing renal neuromodulation of a patient, the apparatus comprising:
- an electric field generator configured for operation external to the patient;
a first element sized and shaped for intravascular placement within a first renal blood vessel of the patient, the first element comprising a first electrode electrically coupled to the electric field generator; and
a second element sized and shaped for intravascular placement within a second renal blood vessel of the patient different than the first renal blood vessel, the second element comprising a second electrode electrically coupled to the electric field generator,wherein the apparatus is configured for delivery of an electric field between the first electrode and the second electrode to at least partially denervate a single kidney while the first element is located within the first renal blood vessel and the second element is located within the second renal blood vessel.
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Abstract
Methods and apparatus are provided for multi-vessel neuromodulation, e.g., via a pulsed electric field. Such multi-vessel neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, the multi-vessel neuromodulation is applied to neural fibers that contribute to renal function. Such multi-vessel neuromodulation optionally may be performed bilaterally.
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Citations
8 Claims
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1. An apparatus for performing renal neuromodulation of a patient, the apparatus comprising:
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an electric field generator configured for operation external to the patient; a first element sized and shaped for intravascular placement within a first renal blood vessel of the patient, the first element comprising a first electrode electrically coupled to the electric field generator; and a second element sized and shaped for intravascular placement within a second renal blood vessel of the patient different than the first renal blood vessel, the second element comprising a second electrode electrically coupled to the electric field generator, wherein the apparatus is configured for delivery of an electric field between the first electrode and the second electrode to at least partially denervate a single kidney while the first element is located within the first renal blood vessel and the second element is located within the second renal blood vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification