Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions
First Claim
1. A system for producing an asynchronous neural response in a patient, the system comprising:
- a pulse generator having a machine-readable medium with first instructions that, when executed, cause the pulse generator to transmit an electrical stimulation signal having a frequency, and second instructions that, when executed adjust the frequency of the electrical stimulation signal;
an electrode coupleable to the pulse generator to deliver the electrical stimulation signal to a target neural population of the patient; and
a sensor positionable to detect a neural response to the electrical stimulation signal,wherein the second instructions adjust the frequency of the electrical stimulation signal in response to an input from the sensor.
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Abstract
Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
420 Citations
21 Claims
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1. A system for producing an asynchronous neural response in a patient, the system comprising:
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a pulse generator having a machine-readable medium with first instructions that, when executed, cause the pulse generator to transmit an electrical stimulation signal having a frequency, and second instructions that, when executed adjust the frequency of the electrical stimulation signal; an electrode coupleable to the pulse generator to deliver the electrical stimulation signal to a target neural population of the patient; and a sensor positionable to detect a neural response to the electrical stimulation signal, wherein the second instructions adjust the frequency of the electrical stimulation signal in response to an input from the sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for treating a patient'"'"'s pain, comprising:
an implantable pulse generator coupleable to an implantable signal delivery device and programmed with instructions that, when executed; direct an electrical stimulation signal to a target neural population, and respond to an indication corresponding to a synchronous neural response from the target neural population by adjusting a frequency of the electrical stimulation signal within a range from 3.0 kHz to 10 kHz. - View Dependent Claims (9, 10, 13)
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11. A system for treating a patient'"'"'s pain, comprising:
an implantable pulse generator coupleable to an implantable signal delivery device and programmed with instructions that, when executed; determine a baseline level for an action potential generated by a target neural population, direct an electrical stimulation signal to the target neural population, and respond to an indication corresponding to a synchronous neural response from the target neural population by adjusting a frequency of the electrical stimulation signal within a range from 3.0 kHz to 10 kHz.
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12. A system for treating a patient'"'"'s pain, comprising:
an implantable pulse generator coupleable to an implantable signal delivery device and programmed with instructions that, when executed; determine a baseline level for an action potential generated by a target neural population, direct an electrical stimulation signal to a target neural population, and respond to an indication corresponding to a synchronous neural response from the target neural population by adjusting a frequency of the electrical stimulation signal within a range from 3.0 kHz to 10 kHz, wherein adjusting the frequency includes increasing the frequency while the action potential is above the baseline level.
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14. A method for configuring a spinal cord stimulation device, the method comprising:
programming the spinal cord stimulation device to; deliver an electrical stimulation signal to a target neural population, and respond to an indication of an action potential generated by the target neural population by adjusting a frequency of the electrical stimulation signal. - View Dependent Claims (15, 16, 17, 18)
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19. A method for configuring a spinal cord stimulation device, the method comprising:
programming the spinal cord stimulation device to; deliver an electrical stimulation signal to a target neural population, respond to an indication of an action potential generated by the target neural population by adjusting a frequency of the electrical stimulation signal, and select a target stimulation frequency based on a decrease in the action potential, wherein programming the spinal cord stimulation device to adjust a frequency of the electrical stimulation signal includes programming the spinal cord stimulation device to increase the frequency of the electrical stimulation signal, and wherein the target stimulation frequency is in a range from 3.0 kHz to 10 kHz.
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20. A method for configuring a spinal cord stimulation device, the method comprising:
programming the spinal cord stimulation device to; deliver an electrical stimulation signal to a target neural population, respond to an indication of an action potential generated by the target neural population by adjusting a frequency of the electrical stimulation signal, and identify a baseline action potential. - View Dependent Claims (21)
Specification