Dose-optimised patient positioning for radiotherapy

• US 9,403,035 B2
• Filed: 08/02/2011
• Issued: 08/02/2016
• Est. Priority Date: 08/02/2011
• Status: Active Grant

• Current Assignee: Brainlab AG
• Original Assignee: Brainlab AG
• Inventors: Gum, Franz, Froehlich, Stephan
• Primary Examiner(s): KIM, ROBERT H
• Assistant Examiner(s): Smith, David E
• Application Number:
  US14/235,904
• Publication Number:
  US 20140171726A1
• Time in Patent Office: 1,827 Days
• Field of Search: 378/65, 600/1, 600/411
• US Class Current: 1/1
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4085 Cone-beams
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 5/1031 using a specific method of dose optimization
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1077 Beam delivery systems

Abstract

The present invention relates to a method for positioning an arrangement of at least one beam position relative to a patient'"'"'s body when the patient is placed for treatment by means of a treatment device which can emit treatment radiation, wherein the at least one beam position describes at least one position of at least one treatment beam, wherein the arrangement is referred to as the treatment arrangement and the treatment beam comprises the treatment radiation, wherein the method is executed by a computer and comprises the following steps:

• providing treatment beam absorption data which describe the absorption properties of the at least part of the body with respect to absorbing the treatment radiation, and the relative position between the at least part of the body and the treatment arrangement;
• providing treatment beam data which describe radiation properties of the at least one treatment beam;
• providing condition data which describe a condition for treating the at least part of the body;
• determining an optimum relative position between the treatment arrangement and the at least part of the body on the basis of the condition data, the treatment beam data and the treatment beam absorption data.

Claims

1. A method for positioning a treatment arrangement of at least one beam position relative to a part of a body of an associated patient when the associated patient is placed for treatment by a treatment device which selectively emits treatment radiation, wherein the at least one beam position describes at least one position of at least one treatment beam, wherein the treatment beam comprises the treatment radiation, wherein the method is executed by a computer and comprises:

a) providing treatment beam absorption data which describe one or more absorption properties of the part of the body with respect to absorbing the treatment radiation, and the relative position between the part of the body and the treatment arrangement;

b) providing treatment beam data which describe one or more radiation properties of the at least one treatment beam;

c) providing condition data which describe a condition for treating the part of the body;

d) determining an optimum relative position between the treatment arrangement and the part of the body based on the condition data, the treatment beam data, and the treatment beam absorption data;

wherein the treatment beam absorption data are provided by determining the one or more absorption properties of the part of the body with respect to absorbing the treatment radiation based on a computed tomography (CT) image and by determining the relative position between the part of the body and the treatment arrangement based on a cone beam computed tomography (CBCT) image.

2. The method according to claim 1, wherein the condition data comprise planning data which describe planned relative positions between the beam positions of a planned arrangement, and wherein the optimum relative position is determined subject to the condition that the relative beam positions of the treatment arrangement are identical to the planned relative positions.

3. The method according to claim 1, wherein image data which are referred to as pre-optimisation image data are provided, which describe an image referred to as the pre-optimisation image which is generated using a medical imaging method at a pre-optimisation time at which the patient is placed for treatment with the treatment beam, and wherein the treatment beam absorption data are determined on the basis of the pre-optimisation image data.

4. The method according to claim 3, wherein the pre-optimisation image data describe a relative position of the treatment arrangement relative to the part of the body, wherein said relative position is referred to as the pre-optimisation relative position and is used to determine the optimum relative position.

5. The method according to claim 1, wherein the treatment beam absorption data describe relative positions between regions of the part of the body and the absorption properties of the regions.

6. The method according to claim 1, wherein the treatment beam absorption data describe the radiation properties of elements of the at least part of the body and relative positions between the elements of the at least part of the body, wherein one of these elements is the at least part of the body to be treated and is referred to as the treatment body part.

7. The method according to claim 6, wherein the relative positions of the elements of the part of the body are determined on the basis of planning image data which describe an image of the part of the body which shows the at least part of the body segmented into the elements, wherein the planning image is generated at a time referred to as the planning time, before the part of the body is placed for the treatment.

8. The method according to claim 7,

wherein image data which are referred to as pre-optimisation image data are provided, which describe an image referred to as the pre-optimisation image which is generated using a medical imaging method at a pre-optimisation time at which the associated patient is placed for treatment with the treatment beam, and wherein the treatment beam absorption data are determined on the basis of the pre-optimisation image data;

wherein the planning image is used to supplement the pre-optimisation image if the pre-optimisation image does not show all the parts through which the at least one treatment beam will pass, wherein the treatment beam absorption data are determined on the basis of the supplemented pre-optimisation image.

9. The method according to claim 1, further comprising:

determining expected dose data which describe an expected dose which is applied to the part of the body, wherein the expected dose is the dose which is expected if the part of the body is in a position relative to the treatment arrangement which is referred to as the expected relative position and is treated by the treatment beam, wherein the expected dose data are determined on the basis of the treatment beam absorption data, the expected relative position and the treatment beam data.

10. The method according to claim 9, wherein the expected relative position is varied in order to determine the expected doses for different expected positions, and wherein the optimum relative position is determined by comparing the different expected doses with the conditions described by the condition data.

11. The method according to claim 9, wherein the part of the body comprises at least one of a target region for which an expected target dose is to be determined and an off-target region for which an expected off-target dose is determined if the treatment arrangement is in the expected relative position, and wherein the condition data comprise conditions for the target region and the off-target region.

12. The method according to claim 1, wherein the treatment beam absorption data are provided based on CBCT image data which describe the CBCT image.

13. The method according to claim 12, wherein the treatment beam absorption data are provided additionally based on the CT image, and wherein CT values of the CT image are used to determine absorption values for elements of the body shown in both the CT image and the CBCT image, and wherein position and geometry of the elements is described by the CBCT image, wherein the CBCT image is generated when the associated patient is placed for treatment and the CT image is generated before the associated patient is placed for treatment.

14. A non-transitory computer readable storage medium comprising a program for positioning a treatment arrangement of at least one beam position relative to a part of a body of an associated patient when the associated patient is placed for treatment by a treatment device which selectively emits treatment radiation, wherein the at least one beam position describes at least one position of at least one treatment beam, wherein the treatment beam comprises the treatment radiation, the program being constituted, when running on a computer or when loaded onto a computer, to cause the computer to perform steps comprising:

a) providing treatment beam absorption data which describe one or more absorption properties of the part of the body with respect to absorbing the treatment radiation, and the relative position between the part of the body and the treatment arrangement;

b) providing treatment beam data which describe one or more radiation properties of the at least one treatment beam;

c) providing condition data which describe a condition for treating the part of the body;

d) determining an optimum relative position between the treatment arrangement and the part of the body based on the condition data, the treatment beam data, and the treatment beam absorption data

wherein the treatment beam absorption data are provided by determining the one or more absorption properties of the part of the body with respect to absorbing the treatment radiation based on a computed tomography (CT) image and by determining the relative position between the part of the body and the treatment arrangement based on a cone beam computed tomography (CBCT) image.

15. A computer comprising the non-transitory computer readable storage medium of claim 14.

16. A radiotherapy system comprising the computer according to claim 15 for positioning the arrangement of the at least one beam position relative to the at least part of the body when the associated patient is placed for treatment by means of the treatment device, the treatment device being designed to emit the at least one treatment beam as defined by the treatment arrangement.

17. A system comprising the computer according to claim 15, the system being operable to position the arrangement of the at least one beam position relative to the part of the body when the associated patient is placed for treatment by means of the treatment device.

18. A method for positioning a treatment arrangement of at least one beam position relative to a part of a body an associated patient when the associated patient is placed for treatment by a treatment device which selectively emits treatment radiation, wherein the at least one beam position describes at least one position of at least one treatment beam, wherein the treatment beam comprises the treatment radiation, wherein the method is executed by a computer and comprises:

a) providing treatment beam absorption data which describe the one or more absorption properties of the part of the body with respect to absorbing the treatment radiation, and the relative position between the part of the body and the treatment arrangement;

b) providing treatment beam data which describe one or more radiation properties of the at least one treatment beam;

c) providing condition data which describe a condition for treating the part of the body;

d) determining an optimum relative position between the treatment arrangement and the part of the body based on the condition data, the treatment beam data, and the treatment beam absorption data;

wherein the condition data comprise planning data which describe planned relative positions between the beam positions of a planned arrangement, and wherein the optimum relative position is determined subject to the condition that the relative beam positions of the treatment arrangement are identical to the planned relative positions.

19. A non-transitory computer readable storage medium comprising a program for positioning a treatment arrangement of at least one beam position relative to a part of a body of an associated patient when the associated patient is placed for treatment by a treatment device which selectively emits treatment radiation, wherein the at least one beam position describes at least one position of at least one treatment beam, wherein the treatment beam comprises the treatment radiation, the program being constituted, when running on a computer or when loaded onto a computer, to cause the computer to perform steps comprising:

a) providing treatment beam absorption data which describe one or more absorption properties of the part of the body with respect to absorbing the treatment radiation, and the relative position between the part of the body and the treatment arrangement;

b) providing treatment beam data which describe one or more radiation properties of the at least one treatment beam;

c) providing condition data which describe a condition for treating the part of the body;

d) determining an optimum relative position between the treatment arrangement and the part of the body based on the condition data, the treatment beam data, and the treatment beam absorption data;

wherein the condition data comprise planning data which describe planned relative positions between the beam positions of a planned arrangement, and wherein the optimum relative position is determined subject to the condition that the relative beam positions of the treatment arrangement are identical to the planned relative positions and wherein the absorption data are provided by determining the absorption properties of the part of the body with respect to absorbing the treatment radiation on the basis of a computed tomography (CT) image and by determining the relative position between the part of the body and the treatment arrangement on the basis of a cone beam computed tomography (CBCT) image.

20. A computer comprising the non-transitory computer readable storage medium of claim 19.

21. A radiotherapy system comprising the computer according to claim 20 for positioning the arrangement of the at least one beam position relative to the at least part of the body when the associated patient is placed for treatment by means of the treatment device, the treatment device being designed to emit the at least one treatment beam as defined by the treatment arrangement.