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Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody

  • US 9,403,902 B2
  • Filed: 10/03/2008
  • Issued: 08/02/2016
  • Est. Priority Date: 10/05/2007
  • Status: Active Grant
First Claim
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1. A method for protection against, treating or alleviating one or more of the effects of an ocular disease associated with amyloid-beta-related pathological abnormalities or changes in the tissues of the visual system in a subject comprising administering intraocularly or intravitreally to the subject a pharmaceutical composition comprising an effective amount of an antibody which binds amyloid-beta, wherein the antibody comprises:

  • (i) a light chain variable region comprising a light chain complementarity determining region (CDR)1 comprising the amino acid sequence of SEQ ID NO;

    9, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO;

    10, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO;

    11; and

    (ii) a heavy chain variable region comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO;

    12, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO;

    13, and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO;

    14,and wherein the ocular disease is cortical visual deficits or cataract.

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