Methods for processing images generated using fourier domain optical coherence tomography (FDOCT)

• US 9,404,730 B2
• Filed: 03/10/2015
• Issued: 08/02/2016
• Est. Priority Date: 01/19/2007
• Status: Active Grant

• Current Assignee: Bioptigen, Inc. (Danaher Corporation)
• Original Assignee: Bioptigen, Inc. (Danaher Corporation)
• Inventors: Buckland, Eric L.
• Primary Examiner(s): IPPOLITO, NICOLE MARIE
• Application Number:
  US14/643,155
• Publication Number:
  US 20150176971A1
• Time in Patent Office: 511 Days
• Field of Search: 382/128, 382/131, 382/132, 382/191, 382/276, 382/280
• US Class Current: 1/1
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 3/117 for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01P 3/36 Devices characterised by the use of optical means, e.g. using infrared, visible, or ultraviolet light G01P3/68 takes precedence; gyrometers using the Sagnac effect, i.e. rotation-induced shifts between counter-rotating electromagnetic beams G01C19/64
• CPC Class Codes: G06T 11/003 Reconstruction from projections, e.g. tomography

Abstract

Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired image does not meet or exceed the quality metric for the acquired image. The acquired image is reprocesses based on the adjusted dispersion correction parameters. The steps of comparing, adjusting and reprocessing are repeated until the acquired image meets or exceeds the quality metric for the acquired image.

Claims

1. A method of managing frequency domain optical coherence tomography (FDOCT) image resolution, comprising:

calibrating a spectrum used to acquire an image of a subject;

setting default dispersion correction parameters;

setting default dispersion management parameters associated with a region of the image of the subject;

acquiring the image of the subject after setting the default dispersion correction parameters and the default dispersion management parameters;

comparing a quality of the acquired image to a quality metric for the acquired image;

adjusting the dispersion correction parameters if the quality of the acquired image does not meet or exceed the quality metric for the acquired image;

reprocessing the acquired image based on the adjusted dispersion correction parameters; and

repeating comparing, adjusting and reprocessing until the acquired image meets or exceeds the quality metric for the acquired image.

2. The method of claim 1, wherein setting the default dispersion correction parameters comprises setting the default dispersion correction parameters to zero.

3. The method of claim 1, wherein the step of acquiring the image is performed before calibrating the spectrum.

4. The method of claim 1, wherein calibrating the spectrum comprises calibrating a spectrometer used to acquire an image of a subject.

5. The method of claim 1, wherein repeating is followed by storing the adjusted dispersion correction parameters as the default dispersion correction parameters for a class of subjects.

6. The method of claim 5, wherein acquiring the image comprises acquiring a first image, the method further comprising processing a second image of a same subject or another subject in the class using the stored adjusted dispersion correction parameters.

7. The method of claim 1, wherein acquiring the image is followed by automatically optimizing the acquired image without any user intervention.

8. The method of claim 7, wherein the comparing, adjusting, reprocessing and repeating are performed automatically to optimize the acquired image without any user intervention for a class of subjects.

9. The method of claim 1, wherein processing comprises distributing the processing among two or more central processing units (CPUs) to reduce processing time.

10. The method of claim 1, wherein acquiring the image is followed by:

displaying the acquired image;

choosing a line or frame for optimization;

selecting a region on the chosen line or frame to optimize; and

reprocessing the acquired image based on the selected region on the chosen line or frame.

11. The method of claim 1, wherein the region of the image comprises a three dimensional volume, a two dimensional frame or subset of a frame, a line or a subset of a line.

12. The method of claim 1, wherein acquiring the image comprises:

selecting a portion of a target subject to be imaged in a control window using an overlay tool; and

acquiring and processing the image based on the selected portion of the acquired image.

13. The method of claim 12, wherein the selected portion of the acquired image has a shape that is quadrilateral, annular, circular or linear.

14. The method of claim 9, wherein acquiring and processing comprises acquiring and processing the image in real time as the portion of the acquired image is selected in the control window.