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Method of producing a multi-microchannel, flow-through element and device using same

  • US 9,404,882 B2
  • Filed: 12/02/2010
  • Issued: 08/02/2016
  • Est. Priority Date: 08/11/2005
  • Status: Active Grant
First Claim
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1. A method of using a multi-microchannel, flow-through element as a transducer or electrode in an electrochemical sensor, comprising:

  • applying a polarization potential between the multi-microchannel, flow-through element as a working electrode and a further, reference electrode;

    exposing the multi-microchannel, flow-through element to a sample containing an analyte;

    detecting as a signal a physico-chemical change as a result of interactions between the analyte in the sample and a complementary biorecognition agent, wherein said complementary biorecognition agent is immobilized in real time on at least one surface of the multi-microchannel flow-through element,wherein the multi-microchannel, flow-through element is provided for use in an electrochemical sensor, and wherein the multi-microchannel, flow-through element is provided as a transducer and is an electrically conductive, metallic element,wherein the multi-microchannel, flow-through element includes a body and a plurality of microchannels, wherein each of said microchannels extends completely through the body of the multi-microchannel, flow-through element and provides a direct flow path between opposite faces of said multi-microchannel, flow-through element.

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