Systems, devices and methods for improving accuracy of biosensors using fill time
First Claim
1. A method for determining a concentration of an analyte in a sample, the method comprising:
- detecting a presence of the sample in an electrochemical sensor having two spaced electrodes;
determining a fill time of the sample in the electrochemical sensor;
calculating a prepulse time using the determined fill time;
reacting an analyte to cause a physical transformation of the analyte between the two electrodes;
applying a potential between the two spaced electrodes for a time period equal to the prepulse time;
determining a first concentration of the analyte in the sample using the two electrodes;
calculating a correction factor in view of the determined fill time; and
determining a corrected analyte concentration based on the first analyte concentration and the correction factor.
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Accused Products
Abstract
Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, the method includes detecting a presence of a sample in an electrochemical sensor including two electrodes. A fill time of the sample is determined with the two electrodes and a correction factor is calculated in view of at least the fill time. The method also includes reacting an analyte that causes a physical transformation of the analyte between the two electrodes. A concentration of the analyte can then be determined in view of the correction factor with the same two electrodes. Systems and devices that take advantage of the fill time to make analyte concentration determinations are also provided.
107 Citations
30 Claims
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1. A method for determining a concentration of an analyte in a sample, the method comprising:
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detecting a presence of the sample in an electrochemical sensor having two spaced electrodes; determining a fill time of the sample in the electrochemical sensor; calculating a prepulse time using the determined fill time; reacting an analyte to cause a physical transformation of the analyte between the two electrodes; applying a potential between the two spaced electrodes for a time period equal to the prepulse time; determining a first concentration of the analyte in the sample using the two electrodes; calculating a correction factor in view of the determined fill time; and determining a corrected analyte concentration based on the first analyte concentration and the correction factor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An electrochemical system, comprising:
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(a) an electrochemical sensor including electrical contacts configured to mate with a test meter, the electrochemical sensor comprising; (i) a first electrode and a second electrode in a spaced apart relationship, and (ii) a reagent; and (b) the test meter including a processor configured to determine a fill time of a sample, calculate a prepulse time using the determined fill time, receive current data from the electrochemical sensor upon application of a voltage to the electrochemical sensor for a period of time equal to the calculated prepulse time, and determine a corrected analyte concentration of a sample based on a calculated concentration of an analyte and a correction factor, the correction factor being based upon the determined fill time of the sample in the electrochemical sensor. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification