System and method for determining arterial compliance and stiffness

• US 9,408,541 B2
• Filed: 08/04/2014
• Issued: 08/09/2016
• Est. Priority Date: 08/04/2014
• Status: Active Grant

• Current Assignee: Yamil Kuri
• Original Assignee: Yamil Kuri
• Inventors: Kuri, Yamil
• Primary Examiner(s): Jackson, Gary
• Assistant Examiner(s): SANDS, DAVIN K
• Application Number:
  US14/450,424
• Publication Number:
  US 20160029901A1
• Time in Patent Office: 736 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0891 for diagnosis of blood vessels
• CPC Class Codes: A61B 8/5223 for extracting a diagnostic or physiological parameter from medical diagnostic data for algorithms to analyse biomedical images G06T7/0012
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject'"'"'s heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject'"'"'s heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.

Claims

1. A system for calculating an arterial compliance index for determining the arterial stiffness of an artery of a subject consisting of:

a blood pressure monitoring device configured to measure a systolic blood pressure reading and a diastolic blood pressure reading for the artery of the subject;

a blood flow velocity monitoring device configured to measure a peak-systolic blood flow velocity, wherein the peak-systolic blood flow velocity is a first measure of velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject'"'"'s heart muscle, and an end-diastolic blood flow velocity, wherein the end-diastolic blood flow velocity is a second measure of velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of relaxation of the subject'"'"'s heart muscle; and

a central processing unit configured to calculate the arterial compliance index as a function of the subject'"'"'s;

(a) systolic blood pressure reading as measured by the blood pressure monitoring device,

(b) diastolic blood pressure reading as measured by the blood pressure monitoring device,

(c) peak-systolic blood flow velocity determined during the systolic phase of contraction of the subject'"'"'s heart muscle, and

(d) end-diastolic blood flow velocity determined during a period of relaxation of the subject'"'"'s heart muscle.

2. The system of claim 1, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of systolic pressure, pulse pressure and a systolic resistive index, wherein the pulse pressure is defined as the difference between the systolic pressure and diastolic pressure and the systolic resistive index is a quotient determined by a proportion of a first part, wherein the first part is the difference between the peak-systolic velocity and end-diastolic velocity, and a second part, wherein the second part is the peak-systolic velocity.

3. The system of claim 1, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of diastolic pressure, pulse pressure and a diastolic resistive index, wherein the pulse pressure is defined as the difference between the systolic pressure and diastolic pressure and the diastolic resistive index is a quotient determined by a proportion of a first part, wherein the first part is the difference between the peak-systolic velocity and end-diastolic velocity, and a second part, wherein the second part is the end-diastolic velocity.

4. The system of claim 1, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of diastolic pressure, systolic pressure, end-diastolic velocity and peak-systolic velocity, wherein the arterial compliance index is a quotient determined by a proportion of a first part, wherein the first part is the difference between a first product of the peak-systolic velocity and the diastolic pressure and a second product of the end diastolic velocity and the systolic pressure, and a second part, wherein the second part is the difference between the peak-systolic velocity and end-systolic velocity.

5. The system of claim 1, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of:

(a) a first area index of the artery, wherein the first area index of the artery is a quotient determined by a proportion of a first part, wherein the first part is the difference in peak-systolic velocity and end-diastolic velocity and a second part, wherein the second part is the difference in systolic pressure and diastolic pressure, and

(b) a second area index of the artery, wherein the second area index of the artery represents the area of the artery that is generating an arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases.

6. The system of claim 1, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of:

(a) a first area index of the artery, wherein the first area index of the artery is a quotient determined by a proportion of a first part, wherein the first part is the difference in peak-systolic velocity and end-diastolic velocity and a second part, wherein the second part is the difference in systolic pressure and diastolic pressure, and

(b) the stiffness limit of the artery, wherein the stiffness limit of the artery is defined to be at a point where the first area index of the artery is substantially equal to a second area index of the artery, wherein the second area index of the artery represents the area of the artery that is generating an arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases.

7. The system of claim 1, wherein the central processing unit is configured to calculate the arterial compliance index by selectably employing at least one of the following:

(a) pulse pressure;

(b) systolic vascular resistance pressure;

(c) diastolic vascular resistance pressure;

(d) systolic resistive index;

(e) diastolic resistive index;

(f) vascular resistance index;

or

(g) cardiac output index.

8. The system of claim 1, wherein the central processing unit interfaces with the blood pressure monitoring device.

9. The system of claim 1, wherein the central processing unit interfaces with the blood flow velocity monitoring device.

10. The system of claim 1, wherein the central processing unit interfaces with the blood pressure monitoring device and with the blood flow velocity monitoring device.

11. The system of claim 1, wherein the blood pressure monitoring device, the blood flow velocity monitoring device, and the central processing unit, comprise a single unitary device.

12. The system of claim 1, wherein the central processing unit receives blood pressure readings by selectably employing at least one of the following:

(a) key data entry;

(b) electronic data transfer;

or

(c) wireless data transfer.

13. The system of claim 1, wherein the central processing unit receives blood velocity readings by selectably employing at least one of the following:

(a) key data entry;

(b) electronic data transfer;

or

(c) wireless data transfer.

14. The system of claim 1, wherein the blood pressure monitoring device is a brachial cuff blood pressure device.

15. The system of claim 1, wherein the blood pressure monitoring device is a catheter.

16. The system of claim 1, wherein the blood pressure monitoring device is configured to measure the blood pressure of the subject by measuring the blood pressure at one or more segments of a limb of the subject.

17. The system of claim 1, wherein the blood pressure monitoring device is configured to measure the blood pressure of the subject by measuring the blood pressure at one or more segments of an artery of the subject.

18. The system of claim 1, wherein the blood flow velocity monitoring device is a Doppler ultrasound.

19. The system of claim 1, wherein the blood flow velocity monitoring device is a magnetic resonance imaging device.

20. The system of claim 1, wherein the blood flow velocity monitoring device is configured to measure the blood flow of the subject by measuring the blood flow velocity at one or more segments of at least one artery of the subject.

21. The system of claim 1, wherein the arterial compliance index is determined in real time or near real time.

22. A method for calculating an arterial compliance index for determining the arterial stiffness of an artery of a subject consisting of:

providing a blood pressure monitoring device to measure a systolic blood pressure reading and a diastolic blood pressure reading for the artery of the subject;

determining the systolic blood pressure reading for the subject;

determining the diastolic blood pressure reading for the subject;

configuring a blood flow velocity monitoring device to measure a peak-systolic blood flow velocity, wherein the peak-systolic blood flow velocity is a first measure of velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject'"'"'s heart muscle, and an end-diastolic blood flow velocity, wherein the end-diastolic blood flow velocity is a second measure of velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of relaxation of the subject'"'"'s heart muscle;

determining the peak-systolic blood flow velocity, wherein the peak-systolic blood flow velocity is the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject'"'"'s heart muscle;

determining the end-diastolic blood flow velocity, wherein the end-diastolic blood flow velocity is the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of relaxation of the subject'"'"'s heart muscle; and

configuring a central processing unit to calculate the arterial compliance index as a function of the subject'"'"'s;

(a) systolic blood pressure reading as measured by the blood pressure monitoring device,

(b) diastolic blood pressure reading as measured by the blood pressure monitoring device,

(c) peak-systolic blood flow velocity determined during the systolic phase of contraction of the subject'"'"'s heart muscle, and

(d) end-diastolic blood flow velocity determined during a period of relaxation of the subject'"'"'s heart muscle.

23. The method of claim 22, wherein the central processing unit is further configured to calculate the arterial compliance index as a function of systolic pressure, pulse pressure and a systolic resistive index, wherein the pulse pressure is the difference between the systolic pressure and diastolic pressure and the systolic resistive index is a quotient determined by a proportion of a first part, wherein the first part is the difference between the peak-systolic velocity and end-diastolic velocity, and a second part, wherein the second part is the peak-systolic velocity.

24. The method of claim 22, wherein the central processing unit is further configured to calculate the arterial compliance index as a function of diastolic pressure, pulse pressure and a diastolic resistive index, wherein the pulse pressure is the difference between the systolic pressure and diastolic pressure and the diastolic resistive index is a quotient determined by a proportion of a first part, wherein the first part is the difference between the peak-systolic velocity and end-diastolic velocity, and a second part, wherein the second part is the end-diastolic velocity.

25. The method of claim 22, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of diastolic pressure, systolic pressure, end-diastolic velocity and peak-systolic velocity, wherein the arterial compliance index is a quotient determined by a proportion of a first part, wherein the first part is the difference between a first product of the peak-systolic velocity and the diastolic pressure and a second product of the end-diastolic velocity and the systolic pressure, and a second part, wherein the second part is the difference between the peak-systolic velocity and end-systolic velocity.

26. The method of claim 22, wherein the central processing unit is configured to calculate the arterial compliance index as a further function of:

(a) a first area index of the artery, wherein the first area index of the artery is a quotient determined by a proportion of a first part, wherein the first part is the difference in peak-systolic velocity and end-diastolic velocity and a second part, wherein the second part is the difference in systolic pressure and diastolic pressure, and

(b) a second area index of the artery, wherein the second area of the artery represents the area of the artery that is generating an arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases.

27. The method of claim 22, wherein the central processing unit is configured to calculate the arterial compliance index as a function of:

(a) a first area index of the artery, wherein the first area index of the artery is a quotient determined by a proportion of a first part, wherein the first part is the difference in peak-systolic velocity and end-diastolic velocity and a second part, wherein the second part is the difference in systolic pressure and diastolic pressure, and

(b) the stiffness limit of the artery, wherein the stiffness limit of the artery is defined to be at a point where the first area index of the artery is substantially equal to a second area index of the artery, wherein the second area of the artery represents the area of the artery that is generating an arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases.

28. The method of claim 22, wherein the central processing unit is further configured to calculate the arterial compliance index by selectably employing at least one of the following:

(a) pulse pressure;

(b) systolic vascular resistance pressure;

(c) diastolic vascular resistance pressure;

(d) systolic resistive index;

(e) diastolic resistive index;

(f) vascular resistance index;

or

(g) cardiac output index.

29. The method of claim 22, further comprising comparing the arterial compliance index of the artery of the subject with a second arterial compliance index derived from a mean reading of a segment of a population.

30. The method of claim 22, further comprising comparing the arterial compliance index of the artery of the subject with a second arterial compliance index derived from one or more segments of the artery.