Non-invasive method and system for characterizing cardiovascular systems for all-cause mortality and sudden cardiac death risk
First Claim
1. A method for quantifying the risk of serious arrhythmias, sudden cardiac death, or other modes of death and all-cause mortality events in mammals, comprising:
- obtaining ECG data, the ECG data comprising at least one heart beat cycle;
processing the ECG data to detect patterns that predict a risk of sudden cardiac death, other modes of death, and all-cause mortality, the processing being performed without the use of data from other measuring devices or invasive procedures, the ECG data including at least 12 dimensional dynamical phase space densities, the processing including using a time interval to quantify the risk of sudden cardiac death, other modes of death, and all-cause mortality; and
creating a 3-D phase space plot from processed ECG data, the 3-D phase space plot visualization providing a visual indication of regions of a heart that include abnormal heart tissue,wherein the at least one heart beat cycle corresponds to a vector sum electrical activation pathway through the heart, andwherein the vector sum electrical activation pathway is used with time information associated with the at least 12 dimensional dynamical space density to determine the risk of sudden cardiac death, other modes of death and all-cause mortality.
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Abstract
Methods and systems for evaluating the electrical activity of the heart to identify novel ECG patterns closely linked to the subsequent development of serious heart rhythm disturbances and fatal cardiac events. Two approaches are describe, for example a model-based analysis and space-time analysis, which are used to study the dynamical and geometrical properties of the ECG data. In the first a model is derived using a modified Matching Pursuit (MMP) algorithm. Various metrics and subspaces are extracted to characterize the risk for serious heart rhythm disturbances, sudden cardiac death, other modes of death, and all-cause mortality linked to different electrical abnormalities of the heart. In the second method, space-time domain is divided into a number of regions (e.g., 12 regions), the density of the ECG signal is computed in each region and input to a learning algorithm to associate them with these events.
18 Citations
19 Claims
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1. A method for quantifying the risk of serious arrhythmias, sudden cardiac death, or other modes of death and all-cause mortality events in mammals, comprising:
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obtaining ECG data, the ECG data comprising at least one heart beat cycle; processing the ECG data to detect patterns that predict a risk of sudden cardiac death, other modes of death, and all-cause mortality, the processing being performed without the use of data from other measuring devices or invasive procedures, the ECG data including at least 12 dimensional dynamical phase space densities, the processing including using a time interval to quantify the risk of sudden cardiac death, other modes of death, and all-cause mortality; and creating a 3-D phase space plot from processed ECG data, the 3-D phase space plot visualization providing a visual indication of regions of a heart that include abnormal heart tissue, wherein the at least one heart beat cycle corresponds to a vector sum electrical activation pathway through the heart, and wherein the vector sum electrical activation pathway is used with time information associated with the at least 12 dimensional dynamical space density to determine the risk of sudden cardiac death, other modes of death and all-cause mortality. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for displaying risk of cardiovascular or all-cause mortality event in a mammalian heart, comprising:
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obtaining ECG data for the heart, the ECG data comprising at least one heart beat cycle; processing the ECG data to detect an abnormality in the heart and the risk for sudden cardiac death (SCD) and all-cause mortality without use of other measuring devices or invasive procedures; and using phase information to determine a location of the abnormality to visually display the potential to be arrhythmogenic, wherein the abnormality in the heart is detected within a time interval of between 50 seconds and 700 seconds, wherein the heart beat cycle corresponds to a vector sum electrical activation pathway through the heart, and the pathway is used with at least 12 dimensional dynamical space density time information to determine the risk of sudden cardiac death and all-cause mortality. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification