Uterine lavage for embryo retrieval

• US 9,408,634 B2
• Filed: 12/18/2013
• Issued: 08/09/2016
• Est. Priority Date: 06/21/2013
• Status: Active Grant

• Current Assignee: Butterfly Biosciences Incorporated
• Original Assignee: Previvo Genetics, LLC
• Inventors: Buster, John E., Cesario, Moses, Woodard, Steven Paul
• Primary Examiner(s): GILBERT, SAMUEL G
• Application Number:
  US14/132,235
• Publication Number:
  US 20140378756A1
• Time in Patent Office: 965 Days
• Field of Search: 600573-580, 600 33- 36, 604/27, 604/35, 604/36, 604 39- 43, 604/93.01
• US Class Current: 1/1
• CPC Class Codes: A61B 17/42 Gynaecological or obstetrical instruments or methods ligaturing clamps or clips for the umbilical cord A61B17/122; curettage A61B17/320708; dilators A61M29/00
• CPC Class Codes: A61B 17/435 for embryo or ova transplantation
• CPC Class Codes: A61B 2017/4216 Operations on uterus, e.g. endometrium
• CPC Class Codes: A61B 2050/185 Drawers
• CPC Class Codes: A61B 2050/311 Cases
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61B 2217/007 with irrigation system
• CPC Class Codes: A61B 50/13 Trolleys, e.g. carts

Abstract

A device for recovering one or more blastocysts from the uterus of a human includes an outer guide member for insertion into a cervical canal of the human. The outer guide member includes a distal portion with an activatable seal for isolating the uterus from the external environment and defines a lumen having a longitudinal axis. The device also includes an inner catheter located within the lumen and slidable along the longitudinal axis of the lumen relative to the outer guide member. The inner catheter has a distal tip positionable distally of the seal to extend into the uterus and includes a fluid delivery lumen terminating at a distal fluid delivery port for delivering fluid into the uterus. The device defines a distal suction port for aspirating fluid and entrained blastocysts from the uterus. The distal fluid delivery port and the distal suction port are arranged such that, in use, fluid delivered from the distal fluid delivery port travels through the distal suction port to the uterus.

Claims

1. A device for recovering one or more blastocysts from a uterus of a human, comprising:

an outer guide member for insertion into a cervical canal of the human, the outer guide member including a seal for isolating the uterus from an external environment, the outer guide member defining a lumen having a longitudinal axis;

an inner catheter located within the lumen and slidable along the longitudinal axis of the lumen relative to the outer guide member, the catheter having a distal tip positionable distally of the seal to extend into the uterus,

the inner catheter defining a fluid delivery lumen terminating at a fluid delivery port for delivering fluid into the uterus, and the device defining a suction port for aspirating fluid and entrained blastocysts from the uterus such that in use fluid is deliverable from the fluid delivery port to travel through the suction port to the uterus; and

a priming cap configured to cover the fluid delivery and suction ports to provide sealing to allow priming of the device prior to use.

2. The device of claim 1, wherein the inner catheter includes a tubular member that surrounds the fluid delivery lumen, an outflow lumen for aspirating fluid and entrained blastocysts being defined between the tubular member and the fluid delivery lumen.

3. The device of claim 1, wherein the inner catheter includes an atraumatic tip positioned distally of the fluid delivery port.

4. The device of claim 1, wherein the fluid delivery port is non-circular in shape to provide directional control of fluid spray.

5. The device of claim 1, wherein the seal is activatable, the seal including a balloon collar.

6. The device of claim 1, wherein the seal is activatable, the seal including an expandable foam.

7. The device of claim 1, wherein the outer guide member includes a cervical stop adjustably mounted on the outer guide member relative to the seal for positioning against an external cervical os.

8. The device of claim 7, further comprising markings for setting a distance between the seal and the cervical stop.

9. The device of claim 7, wherein the cervical stop is configured to be clamped in a position along the outer guide member.

10. The device of claim 1, wherein the fluid delivery port comprises two diametrically opposed ports.

11. The device of claim 10, wherein the two ports are non-circular in shape to provide directional control of fluid spray.

12. The device of claim 11 wherein a proximal side of at least one of the ports is perpendicular to the longitudinal axis and a distal side of the at least one of the ports diverges from the longitudinal axis at an obtuse angle.

13. The device of claim 1 further comprising an atraumatic tip, wherein the suction port includes a plurality of fluid suction ports that are defined by the atraumatic tip.

14. A device for recovering one or more blastocysts from a uterus of a human, comprising:

an outer guide member for insertion into a cervical canal of the human, the outer guide member including a seal for isolating the uterus from an external environment, the outer guide member defining a lumen having a longitudinal axis;

an inner catheter located within the lumen and slidable along the longitudinal axis of the lumen relative to the outer guide member, the catheter having a distal tip positionable distally of the seal to extend into the uterus,

the inner catheter defining a fluid delivery lumen terminating at a fluid delivery port for delivering fluid into the uterus, and the device defining a suction port for aspirating fluid and entrained blastocysts from the uterus; and

a priming cap configured to cover the fluid delivery and suction ports to provide sealing to allow priming of the device prior to use.

15. The device of claim 14, wherein the fluid delivery port is defined in a circumferential wall of the fluid delivery lumen such that the fluid is delivered radially from the fluid delivery lumen to travel through the suction port to the uterus.