Inhaled hypertonic saline delivered by a heated nasal cannula
First Claim
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1. An apparatus, comprising:
- a nasal cannula assembly configured to receive at a first end portion a flow of aerosolized medicament, the nasal cannula assembly configured to convey from the first end portion to a second end portion the flow of aerosolized medicament to deliver the flow of aerosolized medicament transnasally to a subject, the nasal cannula assembly configured to limit accumulation of liquid droplets from the flow of aerosolized medicament.
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Abstract
The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
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Citations
25 Claims
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1. An apparatus, comprising:
a nasal cannula assembly configured to receive at a first end portion a flow of aerosolized medicament, the nasal cannula assembly configured to convey from the first end portion to a second end portion the flow of aerosolized medicament to deliver the flow of aerosolized medicament transnasally to a subject, the nasal cannula assembly configured to limit accumulation of liquid droplets from the flow of aerosolized medicament. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus, comprising:
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a nasal cannula assembly having a tube portion and a face piece portion, the tube portion configured to be coupled to an aerosol preparation mechanism, the face piece portion configured to be coupled to a nostril of a subject, the nasal cannula assembly configured to receive, at the tube portion and from the aerosol preparation mechanism, an aerosolized osmolyte, the nasal cannula assembly configured to convey, over a period of at least eighty minutes and via the face piece portion, the aerosolized osmolyte to the nostril of the subject, the nasal cannula assembly configured to limit accumulation of liquid droplets therein. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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21. An apparatus, comprising:
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a nasal cannula assembly having a tube portion and a face piece portion, the tube portion configured to be operably coupled to an aerosol preparation mechanism, the face piece portion configured to be removably coupled to a nostril of a subject, the nasal cannula assembly configured to receive, at the tube portion and from the aerosol preparation mechanism, a flow of aerosolized osmolyte including respirable particles having a particle size of 1-5 microns MMD, the nasal cannula assembly configured to convey, via the face piece portion, the aerosolized osmolyte to the notstril of the subject, the nasal cannula assembly configured to limit accumulation of the aerosolized osmolyte therein. - View Dependent Claims (22, 23, 24, 25)
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Specification