Cardiac rhythm management device with neural sensor

• US 9,409,025 B2
• Filed: 07/21/2010
• Issued: 08/09/2016
• Est. Priority Date: 12/24/2003
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Libbus, Imad, Kramer, Andrew P., Moffitt, Julia
• Primary Examiner(s): Flory, Christopher A
• Application Number:
  US12/840,449
• Publication Number:
  US 20100286741A1
• Time in Patent Office: 2,211 Days
• Field of Search: 607/9, 607/17, 607/22, 607/23
• US Class Current: 1/1
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

Claims

1. An implantable medical device configured to provide a cardiac rhythm management (CRM) therapy to provide a physiologic system with a baseline response and configured to receive feedback from a transient nerve traffic response in a neural target within an autonomic nervous system (ANS), wherein perturbing the physiologic system causes the transient nerve traffic response before nerve traffic at the neural target returns to the baseline response, the device comprising:

a CRM function module configured to apply the CRM therapy using an electrical signal to capture cardiac tissue, wherein the CRM therapy is configured to provide closed-loop cardiac stimulation to selected chambers of the heart in order to treat disorders of cardiac rhythm;

a neural function module configured to sense nerve traffic in the neural target within the ANS; and

a controller connected to the CRM function module and the neural function module, wherein the controller is configured to control the CRM therapy to provide closed-loop cardiac stimulation that causes the baseline response, implement a programmed protocol for receiving the feedback used to control the closed-loop cardiac stimulation, and adjust the CRM therapy using the feedback,

wherein, in implementing the programmed protocol for receiving the feedback, the controller is configured to;

prepare to determine the transient nerve traffic response by perturbing the physiologic system from the baseline response to cause the transient nerve traffic response to the perturbed system, and

determine the transient nerve traffic response to perturbing the physiologic system by monitoring nerve traffic at the neural target within a time period before nerve traffic at the neural target adapts to changes caused by perturbing the physiologic system and returns to the baseline response.

2. The device of claim 1, wherein, in implementing the programmed protocol for receiving the feedback, the controller is configured prepare to determine the transient nerve traffic response by changing a CRM stimulation parameter to cause the transient nerve traffic response.

3. The device of claim 1, wherein, in implementing the programmed protocol for receiving the feedback, the controller is configured prepare to determine the transient nerve traffic response by applying a neural stimulation burst to cause the transient nerve traffic response.

4. The device of claim 1, wherein, in implementing the programmed protocol for receiving the feedback, the controller is configured prepare to determine the transient nerve traffic response by transiently stimulating myocardium.

5. The device of claim 1, wherein the signal indicative of the nerve traffic includes a signal indicative of a nerve traffic pattern, a signal indicative of nerve traffic intensity, or a signal indicative of a nerve traffic pattern and nerve traffic intensity.

6. The device of claim 1, wherein signal processing module is adapted to implement a noise reduction algorithm to identify features of the nerve traffic signal, and the noise reduction algorithm includes a wavelet transformation.

7. The device of claim 1, wherein signal processing module is adapted to implement a noise reduction algorithm to identify features of the nerve traffic signal, and the noise reduction algorithm identifies a pattern and an intensity of the nerve traffic signal.

8. The device of claim 1, wherein the signal processing module includes an amplifier and a filter adapted to process and monitor nerve traffic, wherein the amplifier includes an amplifier with a gain of approximately 1,000 to approximately 99,000, and wherein the filter includes a bandpass filter to pass frequencies in a range from approximately 30 Hz to approximately 3,000 Hz.

9. The device of claim 1, wherein the neural function module is configured to sense nerve traffic from a chemoreceptor that is indicative of a blood gas concentration.

10. The device of claim 1, wherein the neural function module is configured to sense nerve traffic from at least one afferent nerve that is indicative of a blood gas concentration.

11. The device of claim 1, wherein the neural function module is configured to sense nerve traffic from a baroreceptor that is indicative of blood pressure.

12. The device of claim 1, wherein the signal indicative of nerve traffic includes a signal indicative of nerve traffic from at least one afferent nerve that is indicative of blood pressure.