Modulators of methyl modifying enzymes, compositions and uses thereof

• US 9,409,865 B2
• Filed: 05/08/2015
• Issued: 08/09/2016
• Est. Priority Date: 11/18/2011
• Status: Active Grant

• Current Assignee: Constellation Pharmaceuticals Incorporated (Morphosys Ag)
• Original Assignee: Constellation Pharmaceuticals Incorporated (Morphosys Ag)
• Inventors: Albrecht, Brian K., Audia, James Edmund, Gagnon, Alexandre, Harmange, Jean-Christophe, Nasveschuk, Christopher G.
• Primary Examiner(s): CHANDRAKUMAR, NIZAL S
• Application Number:
  US14/707,874
• Publication Number:
  US 20150315148A1
• Time in Patent Office: 459 Days
• Field of Search: 546/261
• US Class Current: 1/1
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 213/64 attached in position 2 or 6
• CPC Class Codes: C07D 213/81 Amides; Imides
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links

Abstract

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Claims

1. A compound having structural formula I-i:

2. A pharmaceutically acceptable composition comprising:

a) the compound of claim 1 or a pharmaceutically acceptable salt thereof; and

b) a pharmaceutically acceptable carrier.

3. The compound of claim 1, wherein the compound is