CDIM binding proteins and uses thereof
First Claim
1. An isolated antibody or antigen-binding fragment thereof that binds to the linear B cell lactosamine antigen CDIM, comprising:
- (a) a heavy chain comprising a CDRH1 having the sequence shown in SEQ ID NO;
76, a CDRH2 having the sequence shown in SEQ ID NO;
77, and a CDRH3 having the sequence shown in any one of SEQ ID NOS;
78-90, 92-98, or 99; and
(b) a light chain comprising (i) a CDRL1 having the sequence shown in SEQ ID NO;
100, a CDRL2 having the sequence shown in SEQ ID NO;
102 and a CDRL3 having the sequence shown in SEQ ID NO;
104, or (ii) a CDRL1 having the sequence shown in SEQ ID NO;
101, a CDRL2 having the sequence shown in SEQ ID NO;
103, and a CDRL3 having the sequence shown in SEQ ID NO;
105.
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Accused Products
Abstract
The present disclosure relates to Cell Death Inducing Molecule (“CDIM”) binding proteins and pharmaceutical compositions thereof. Particularly, the disclosure provides CDIM binding proteins that are useful in the selective depleting and killing of B cells, including neoplastic B cells as well as neoplastic cells that are not of B-cell origin that express CDIM-like antigens. In addition, the disclosure encompasses polynucleotides encoding the disclosed antigen binding proteins, and expression systems for producing the same. Further the present disclosure encompasses methods of treating patients with B cell proliferative- and mediated diseases by administering the CDIM binding proteins as well as diagnostic assays for identifying proteins that bind to CDIM. The disclosure further contemplates diagnostic assays for identifying patient populations that can be treated with the CDIM binding proteins.
48 Citations
23 Claims
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1. An isolated antibody or antigen-binding fragment thereof that binds to the linear B cell lactosamine antigen CDIM, comprising:
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(a) a heavy chain comprising a CDRH1 having the sequence shown in SEQ ID NO;
76, a CDRH2 having the sequence shown in SEQ ID NO;
77, and a CDRH3 having the sequence shown in any one of SEQ ID NOS;
78-90, 92-98, or 99; and(b) a light chain comprising (i) a CDRL1 having the sequence shown in SEQ ID NO;
100, a CDRL2 having the sequence shown in SEQ ID NO;
102 and a CDRL3 having the sequence shown in SEQ ID NO;
104, or (ii) a CDRL1 having the sequence shown in SEQ ID NO;
101, a CDRL2 having the sequence shown in SEQ ID NO;
103, and a CDRL3 having the sequence shown in SEQ ID NO;
105. - View Dependent Claims (2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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4. An isolated antigen binding protein that binds to the linear B cell lactosamine antigen CDIM, comprising a heavy chain variable region sequence selected from the group consisting of SEQ ID NOS:
- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, and 22, and a light chain variable region sequence selected from the group consisting of SEQ ID NOS;
23 and 24.
- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, and 22, and a light chain variable region sequence selected from the group consisting of SEQ ID NOS;
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5. An isolated antigen binding protein that binds to the linear B cell lactosamine antigen CDIM, comprising:
- (a) a heavy chain variable region selected from the group consisting of SEQ ID NO;
1, SEQ ID NO;
2, and SEQ ID NO;
12; and
(b) a light chain variable region selected from the group consisting of SEQ ID NO;
23 and SEQ ID NO;
24.
- (a) a heavy chain variable region selected from the group consisting of SEQ ID NO;
Specification