Mapping ultrasound transducers

• US 9,412,357 B2
• Filed: 12/23/2013
• Issued: 08/09/2016
• Est. Priority Date: 10/14/2009
• Status: Active Grant

• Current Assignee: InSightec Ltd.
• Original Assignee: InSightec Ltd.
• Inventors: Hertzberg, Yoni, Medan, Yoav, Maor, Dov
• Primary Examiner(s): Macchiarolo, Peter
• Assistant Examiner(s): Singer, David L
• Application Number:
  US14/138,864
• Publication Number:
  US 20140112095A1
• Time in Patent Office: 960 Days
• Field of Search: 73/18.2, 73/18.6, 735/84, 600/437, 600/448, 600/459, 324/307, 367/13
• US Class Current: 1/1
• CPC Class Codes: A61B 8/587 Calibration phantoms models for medical purposes G09B23/28
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: G01H 17/00 Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves, not provided for in the preceding groups see provisionally also G01H1/00
• CPC Class Codes: G01N 29/30 Arrangements for calibrating or comparing, e.g. with standard objects
• CPC Class Codes: G10K 11/346 using phase variation

Abstract

Ultrasound transducers may be mapped by varying a focus-affecting parameter and adjusting the parameter so as to improve focus quality. In some embodiments, mapping involves successively varying the phase of one transducer element, or group of elements, with respect to a constant phase of the other transducer elements, and determining the phase at which a tissue displacement in the ultrasound focus is maximized.

Claims

1. A method for mapping an ultrasound transducer comprising a plurality of transducer elements so as to improve a focus thereof, the method comprising:

(a) driving the plurality of transducer elements so as to generate an ultrasound focus;

(b) using acoustic radiation force imaging, measuring a displacement associated with the focus;

(c) grouping the transducer elements;

(d) driving a selected group of transducer elements at a variable phase while driving the other groups of transducer elements at a same constant phase, thereby varying the displacement;

(e) determining a phase difference, if any, between the same constant phase and the variable phase where the displacement is maximized; and

(f) if the phase difference is non-zero, adjusting a relative phase of the selected group of transducer elements based thereon.

2. The method of claim 1 further comprising scanning a profile of the focus.

3. The method of claim 1 further comprising measuring a size of a cross-section of the focus.

4. The method of claim 1 further comprising measuring an integral intensity of the focus.

5. The method of claim 1 further comprising measuring a peak intensity of the focus.

6. The method of claim 1 wherein the acoustic radiation force imaging comprises applying a sequence of MR field gradients.

7. The method of claim 6 wherein the sequence of MR field gradients comprises repeated bipolar gradients.

8. The method of claim 7 wherein step (a) comprises generating an ultrasound pulse synchronized with the sequence of MR field gradients.

9. The method of claim 1 further comprising repeating steps (d) through (f) for the remaining groups of transducer elements.

10. The method of claim 1 further comprising the step of providing a phantom, the driving step generating an ultrasound focus in the phantom and the measuring step measuring a focus quality in the phantom.

11. The method of claim 10 wherein the phantom comprises a material having low tensile strength.

12. The method of claim 11 wherein the phantom comprises a material having a small elastic modulus.

13. A system for mapping an ultrasound transducer so as to improve a focus thereof, the system comprising:

ultrasound transducer hardware for generating an ultrasound focus, the ultrasound transducer hardware comprising an ultrasound transducer having a plurality of transducer elements and associated driver circuitry, the transducer elements being organized in multiple groups of elements;

magnetic-resonance-imaging (MRI) hardware comprising an MRI apparatus and associated driver components for acquiring images of a region comprising the ultrasound focus;

a control station in communication with the ultrasound transducer hardware and the MRI hardware, the control station being configured to

control (i) image acquisition with the MRI hardware and (ii) generation of the ultrasound focus with the ultrasound transducer hardware in accordance with an imaging sequence that specifies the relative timing between image acquisition and ultrasound generation;

process acquired images to determine therefrom a displacement associated with the focus;

send control signals to the ultrasound transducer hardware to vary a phase of a selected group of transducer elements while driving the other groups of transducer elements at a same constant phase; and

adjust the phase of the selected group of transducer elements relative to the same constant phase of the other groups based on a phase difference between the same constant phase and the variable phase where the displacement is maximized.

14. The system of claim 13, wherein the driver circuitry is hardwired to create the groups of transducer elements.

15. The system of claim 13, wherein the driver circuitry comprises switches for configuring the groups of transducer elements.

16. The system of claim 13, wherein the control station comprises separate, intercommunicating computers for controlling the ultrasound transducer hardware and the MRI hardware, respectively.

17. The system of claim 13, wherein the imaging sequence specifies a sequence of MR field gradient synchronized with ultrasound generation.

18. The system of claim 13, wherein controlling image acquisition and ultrasound-focus generation in accordance with an imaging sequence comprises sending trigger signals to the ultrasound transducer hardware and the MRI hardware.

19. The system of claim 13, wherein controlling image acquisition and ultrasound-focus generation in accordance with an imaging sequence comprises communicating a time-delay parameter to the MRI hardware, the MRI hardware being configured to send a trigger signal based on the time-delay parameter to the ultrasound transducer hardware.

20. A method for controlling an ultrasound transducer comprising a plurality of transducer elements organized into groups of elements, the method comprising:

(a) mapping the ultrasound transducer by (i) driving the plurality of transducer elements so as to generate an ultrasound focus in a phantom, (ii) varying a focus-affecting parameter associated with at least one of the groups of elements while driving the other groups of transducer elements at a same constant value of the focus-affecting parameter and measuring a resulting variation on a quality of the ultrasound focus using magnetic-resonance acoustic radiation force imaging, and (iii) selecting a value of the focus-affecting parameter associated with a best focus quality; and

(b) controlling the ultrasound transducer based on the mapping step so as to focus ultrasound into internal body tissue.