Patient permission-based mobile health-linked information collection and exchange systems and methods

• US 9,414,776 B2
• Filed: 03/06/2013
• Issued: 08/16/2016
• Est. Priority Date: 03/06/2013
• Status: Active Grant

• Current Assignee: Navigated Technologies LLC
• Original Assignee: Navigated Technologies LLC
• Inventors: Sillay, Karl Arthur, Birdwell, John Douglas
• Primary Examiner(s): Thomson, William
• Assistant Examiner(s): JIAN, SHIRLEY XUEYING
• Application Number:
  US13/787,406
• Publication Number:
  US 20140257047A1
• Time in Patent Office: 1,259 Days
• Field of Search: 600300-301
• US Class Current: 1/1
• CPC Class Codes: A61B 2034/2065 Tracking using image or pattern recognition
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/064 using markers A61B5/062 takes precedence
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/1101 Detecting tremor
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/4842 Monitoring progression or stage of a disease
• CPC Class Codes: A61M 2210/0687 Skull, cranium
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/37282 characterised by communication with experts in remote locations using a network
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 30/20 for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: G16H 50/70 : for mining of medical data, e.g. analysing previous cases of other patients
• CPC Class Codes: H04L 63/10 : for controlling access to devices or network resources

Abstract

A suite of components comprising an objective measurement medical data collection device and a cohort database may standardize, simplify, and objectify clinical outcomes tracking, culminating in population health measurements within the restorative neurosciences such as Parkinson disease individuals diagnosed with a disease. A data collection device may comprise one or more of a gyroscope, an accelerometer, a locator, a camera and a magnetometer for collecting, for example, data related to tremors experienced by the individuals diagnosed with disease and receive instruction data responsive to evaluation of the collected data in relation to the cohort database. A related method collects objective measurements during phases of treatment such as preoperative symptomatology, probabilistic atlas linked targeting for neuromodulation, accountancy for gravitational effects of brain shift during surgery, measurements of movement and quality of life during supervised treatment and ongoing community and self-directed treatment and provides feedback to implants, intelligent devices and users thereof.

Claims

1. A method for use with a medical mobile communications device, the method for collecting objective medical data, processing the collected medical data and for comparing progress of an individual diagnosed with a neurological disease in relation to a cohort of similar selected individuals diagnosed with the neurological disease, the method for use with the medical mobile communications device comprising:

storing in a memory of the medical mobile communications device a clock time and date with reference to a location of the medical mobile communications device via a programmed computer processor of the medical mobile communications and periodically transmitting the stored clock time, location and date data associated with identity data of the individual diagnosed with the neurological disease via a communications interface connected to the programmed computer processor to a remote server having a medical health record database for storage in the medical health record database, the identity data of the individual diagnosed with the neurological disease being stored in the memory of the medical mobile communications device having been received by an input device and processed by the programmed computer processor of the medical mobile communications device;

storing in the memory associated with the computer processor of the medical mobile communications device objective medical data of the individual diagnosed with the disease, the objective medical data determined using one of a gyroscope and an accelerometer of the medical mobile communications device and processed for storage with the stored clock time, date, location and identity data by the programmed computer processor;

receiving via a communications interface of the medical mobile communications device aggregate objective medical data of the cohort of similar selected individuals diagnosed with the neurological disease according to gender, age and presence or absence of surgical implants comprising one of a deep brain stimulator and a drug delivery system adapted to be implanted in the cohort of similar selected individuals diagnosed with the neurological disease from the remote server having the medical health record database;

comparing by the programmed computer processor the objective medical data of the individual diagnosed with the neurological disease with the aggregate objective medical data of the cohort received via the medical mobile communications device;

repeating the storing of clock time and date, the storing of objective medical data of the individual diagnosed with the neurological disease in memory of the medical mobile communications device, the receiving of the aggregate objective medical data of the cohort from the remote server and the comparing of the objective medical data of the individual diagnosed with the neurological disease with the aggregate objective medical data of the cohort at a later clock time and date determined with reference to location; and

displaying data on a display of the medical mobile communications device indicative of progress of the diagnosed neurological disease of the individual diagnosed with the neurological disease compared to the aggregate objective medical data of the cohort indicative of the progress of the diagnosed neurological disease of the cohort responsive to the repeated comparing of the respective objective medical data of the individual and the aggregate objective medical data of the cohort diagnosed with the neurological disease by the programmed computer processor;

the objective medical data of the individual and the aggregate objective medical data of the cohort diagnosed with the neurological disease comprising extremity movement data, the extremity movement data of the individual diagnosed with the neurological disease comprising at least one of angular acceleration and linear acceleration measurement values over time determined using the one of the gyroscope and the accelerometer of the medical mobile communications device for storage in the memory and processing by the programmed computer processor of the medical mobile communications device adapted to be stored in memory of the medical mobile communications device during pronation/supination movement of a human body extremity of the individual diagnosed with the neurological disease, the medical mobile communications device adapted to be coupled to the human body extremity of the individual diagnosed with the neurological disease.

2. The method for use with the medical mobile communications device of claim 1, the method further including detecting speech of the individual diagnosed with the neurological disease and recording associated speech data in the associated memory of the programmed computer processor of the medical mobile communications device.

3. The method for use with the medical mobile communications device of claim 1 adapted for use with a camera connected to the medical mobile communications device, the method further comprising using the camera to capture video image data of the individual diagnosed with the neurological disease performing human body extremity movement, and

deriving via the programmed computer processor of the medical mobile communications device the objective medical data responsive to receipt of the captured video image data from the camera.

4. The method for use with the medical mobile communications device of claim 1 further comprising determining the direction of gravity via a gravitational sensor of the medical mobile communications device and determining a coordinate frame of reference via the programmed computer processor of the medical mobile communications device, the programmed computer processor using the determined direction of gravity by the gravitational sensor to determine the coordinate frame of reference with respect to the earth.

5. The method for use with the medical mobile communications device of claim 1 further comprising receiving body temperature data of the individual diagnosed with the disease via a body temperature sensor coupled to the medical mobile communications device and, recording the received body temperature data in the associated memory of the medical mobile communications device for comparison with aggregate body temperature data of the cohort diagnosed with the neurological disease received via the communications interface from the remote medical record database.

6. The method for use with the medical mobile communications device of claim 1, the communications interface of the medical mobile communications device further communicating with a neuro-stimulator adapted to be implanted in a brain of the individual diagnosed with the neurological disease, the communications interface for communicating neuro-stimulator control data computed by the programmed computer processor of the medical mobile communications device to the neuro-stimulator for modifying the neuro-stimulator operation via feedback.

7. The method for use with the medical mobile communications device of claim 6, the neuro-stimulator adapted to be implanted in the brain of the individual diagnosed with the neurological disease comprising a remotely controllable deep brain stimulator adapted to be implanted in the brain of the individual diagnosed with the neurological disease.

8. The method for use with the medical mobile communications device of claim 1, the communications interface further communicating with a drug delivery system adapted to be implanted in the individual diagnosed with the neurological disease, the communications interface transferring drug delivery system control data computed by the programmed computer processor of the medical mobile communications device to the drug delivery system for automatically varying an amount of drug for delivery by the drug delivery system to the individual diagnosed with the neurological disease.

9. The method for use with the medical mobile communications device of claim 1, the communications interface cooperating with the display and programmed computer processor of the medical mobile communications device, the programmed computer processor executing software for calculating responsive to the received objective medical data of the individual diagnosed with the neurological disease and the display displaying, responsive to the calculating, a recommended medication dosage and identity of medication adapted to be administered to the individual diagnosed with the neurological disease.

10. The method for use with the medical mobile communications device of claim 1, the communications interface outputting to the display responsive to the programmed computer processor of the medical mobile communications device, the programmed computer processor executing software for calculating and the display displaying, responsive to the calculating, a recommended human body extremity movement program comprising forearm pronation/supination adapted for use by the individual with the diagnosed neurological disease, the at least one of collected pronation/supination angular acceleration and linear acceleration data of the individual diagnosed with the neurological disease for comparison by the programmed computer processor with aggregate forearm pronation/supination data of the cohort diagnosed with the neurological disease received from the remote medical record database and further outputting a rating of the individual diagnosed with the disease relative to the selected cohort.

11. The method for use with the medical mobile communications device of claim 1 further comprising receiving barometric pressure from a barometer coupled to the medical mobile communications device and receiving environmental temperature from a thermometer coupled to the medical mobile communications device at a location indicated by a global positioning system of the medical mobile communications device for storage in the associated memory of the programmed computer processor of the medical mobile communications device.

12. The method for use with the medical mobile communications device of claim 11 further comprising receiving and storing environmental humidity data and perspiration data of the individual diagnosed with the neurological disease, the environmental humidity and perspiration data output by a meter coupled to the medical mobile communications device.

13. The method for use with the medical mobile communications device of claim 1 for selection of the cohort of similar individuals diagnosed with the neurological disease, the medical mobile communications device adapted for receiving input data by the individual diagnosed with the neurological disease, the individual input data comprising age, gender, body weight, presence or absence of surgical implants comprising one of a deep brain stimulator and a drug delivery system and personal identification data of the individual diagnosed with the neurological disease for transmittal to the remote server via the communications interface.

14. The method for use with the medical mobile communications device of claim 1 wherein the neurological disease comprises Parkinson'"'"'s disease.

15. The method for use with the medical mobile communications device of claim 1 wherein the neurological disease comprises one of Parkinson'"'"'s disease, Alzheimer'"'"'s disease, dementia, epilepsy, multiple sclerosis, essential tremor, dystonia, hydrocephalus, a spinal disorder, a gait disorder and stroke.

16. The method for use with the medical mobile communications device of claim 1, the medical mobile communications device adapted to be one of worn or implanted at a wrist location of a left or right arm extremity of a human body.

17. The method for use with the medical mobile communications device of claim 1 further comprising using a pressure transducer of the medical mobile communications device to measure pressure of a human body extremity.

18. The method for use with the medical mobile communications device of claim 1 further comprising sensing oxygen level via a pulse oximeter connected to the medical mobile communications device, the pulse oximeter further adapted to sense oxygen level of blood of the individual diagnosed with the neurological disease.

19. The method for use with the medical mobile communications device of claim 1 further comprising measuring pressure via a pressure transducer adapted to be connected to a human body extremity by one of clothing or a tether, the pressure transducer coupled to the programmed computer processor of the medical mobile communications device adapted to measure relative use of the human body extremity.

20. The method for use with the medical mobile communications device of claim 19 wherein the foot extremity comprises an ankle.

21. The method for use with the medical mobile communications device of claim 1 wherein the extremity movement data adapted to be input to the device determined using the one of the gyroscope and the accelerometer comprises one of forearm pronation and supination data, the extremity movement data comprising pronation/supination movements of the forearm according to a pronation protocol adapted for use by the individual diagnosed with the neurological disease and the method further comprising inputting the extremity movement data determined using the one of the gyroscope and the accelerometer to the programmed computer processor of the medical mobile communication device adapted for assessing bradykinesia of the individual diagnosed with the neurological disease.

22. The method for use with the medical mobile communications device of claim 1 further comprising determining global position data by a global position system connected to the programmed computer processor of the medical mobile communications device of a location of the medical mobile communications device when coupled to the human body extremity of the individual diagnosed with a neurological disease and determining by the programmed computer processor time zone data for transmitting a universal time and date determined by the device and transmitting the objective medical data of the individual for storage at the remote server.

23. The method for use with the medical mobile communications device of claim 1, further comprising receiving aggregate objective medical data of the cohort diagnosed with the neurological disease at the medical mobile communications device via the communications interface in response to sending a query by the communications interface to the remote server having the medical health record database.

24. A method for use with a medical mobile communications device adapted for obtaining medical measurement data from an individual diagnosed with a neurological disease, the method comprising:

processing the medical measurement data by a programmed computer processor of the medical mobile communications device,

computing objective measurement data by the programmed computer processor of the medical mobile communications device from the processed medical measurement data, and

transmitting the computed objective measurement data of the individual diagnosed with the neurological disease for storage in a remote medical health record database, the method for use with a medical mobile communications device further comprising;

determining and periodically storing in a memory of the programmed computer processor and transmitting by a communications interface of the medical mobile communications device for storage at the remote medical record database a universal time of day and date of receipt of the computed objective measurement data of the individual diagnosed with the neurological disease associated with location data of the medical mobile communications device;

communicating by the communications interface of the medical mobile communications device with the remote medical health record database for storing the computed objective measurement data, the objective measurement data obtainable from the medical measurement data input to the programmed computer processor from a sensor adapted for sensing extremity movement data from a pronation/supination protocol adapted to be performed by the individual diagnosed with the neurological disease for storage in memory of the medical mobile communications device and for communication to the remote medical health record database;

collecting the extremity movement data of the pronation/supination protocol from the sensor comprising one of a gyroscope and an accelerometer of the medical mobile communications device, the extremity movement data adapted to be obtained from the of angular and linear acceleration measurements calculated with respect to at least three axes of a distinguished coordinate system adapted for the pronation/supination protocol and universal time and date, the medical mobile communications device adapted to be coupled to a human body extremity of the individual diagnosed with the neurological disease;

receiving individual identity data input for storage in memory of the medical mobile communications device;

storing the one of collected angular and linear acceleration measurement data of the individual diagnosed with the neurological disease in memory of the medical mobile communications device with the stored individual identity data;

determining a direction of maximum motion of the extremity of the individual diagnosed with the neurological disease by the programmed computer processor of the medical mobile communications device adapted to be coupled to the extremity of the individual from at least a subset of the collected extremity movement data and using the determined direction to compute the objective measurement data; and

communicating the computed objective measurement data via the communications interface of the medical mobile communications device, said computed objective measurement data comprising an estimate of a variation present in the collected objective measurement data and the universal time of day and date, to the remote medical health record database,

the programmed computer processor of the medical mobile communications device actuating a display of the medical mobile communications device adapted for displaying the computed objective measurement data of the individual diagnosed with the neurological disease responsive to the computing.

25. The method for use with the medical mobile communications device of claim 24, the one of angular and linear acceleration measurement data adapted to be collected responsive to forearm pronation/supination movements by the individual diagnosed with the neurological disease over time and according to the pronation/supination protocol.

26. The method for use with the medical mobile communications device of claim 24, the method further comprising determining the direction and value of maximum motion in the distinguished coordinate system adapted to be determined of the extremity during pronation/supination movements performed by the individual diagnosed with the neurological disease, the determining of direction and value performed by the programmed computer processor of the remote medical health record database responsive to the sensor.

27. A method for use with a medical mobile communications device adapted for use by an individual diagnosed with a neurological disease and having an associated, activatable deep brain stimulator adapted to be implanted in the individual diagnosed with the neurological disease, the medical mobile communications device comprising one of a gyroscope and an accelerometer, a communications interface, and a programmed computer processor of the medical mobile communications device, wherein the programmed computer processor executes software for:

computing a distinguished coordinate system, a distinguished coordinate of the distinguished coordinate system adapted to value a greatest motion of the individual diagnosed with the disease and using the distinguished coordinate system adapted to determine forearm extremity motion data comprising a value of one of maximum rate of angular acceleration, of degrees traveled per oscillation of a forearm extremity, peak angular velocity and of hesitation over time, data for computing the forearm extremity motion data adapted to be sensed by one of an accelerometer and a gyroscope for input to the programmed computer processor, the forearm extremity motion data adapted to be collected responsive to forearm extremity pronation/supination movements by the individual diagnosed with the neurological disease and stored in memory associated with the programmed computer processor;

the programmed computer processor calculating and the memory storing the forearm extremity motion data during pronation/supination and adapted for storing the forearm extremity motion data in accordance with the distinguished coordinate system, the forearm extremity motion data correlating with a clinical rating scale for the diagnosed neurological disease, the forearm extremity motion data responsive to deep brain stimulation activation and deactivation via the communications interface of the medical mobile communications device;

receiving, via the communications interface of the medical mobile communications device, aggregate forearm extremity motion data of a cohort of similar selected individuals diagnosed with the neurological disease according to gender, age and one of presence or absence of surgical implants comprising one of a deep brain stimulator and a drug delivery system relative to the individual diagnosed with the disease, the aggregate data calculated according to a clinical rating scale for the diagnosed disease;

calculating clinical rating score data of the individual diagnosed with the disease;

comparing the forearm extremity motion data of the individual diagnosed with the disease to the cohort according to the clinical rating scale for the diagnosed neurological disease; and

displaying relative values of the forearm extremity motion data calculated according to the clinical rating scale for the diagnosed neurological disease for display by a display of the medical mobile communications device.

28. The method for use with the medical mobile communications device of claim 27 further comprising a magnetometer for detecting a magnetic field of an electromotor and an alerter of the medical mobile communications device, the alerter, responsive to a magnetic field above an average magnetic field acquired within the cohort, adapted to alert the individual diagnosed with the neurological disease of the magnetic field value above the average magnetic field acquired within the cohort.

29. The method for use with the medical mobile communications device of claim 27 further comprising an associated medical drug delivery system adapted to be implanted in the individual diagnosed with the neurological disease, the method further comprising the communications interface communicating drug delivery control data to the medical drug delivery system, the programmed computer processor calculating the drug delivery control data.

30. The method for use with the medical communications device of claim 27, the diagnosed neurological disease being Parkinson'"'"'s disease and the clinical rating scale for the diagnosed neurological disease being a unified Parkinson'"'"'s disease rating scale.