Systems and methods for making and using an electrical stimulation system with photonic stimulation capabilities

• US 9,415,154 B2
• Filed: 11/11/2013
• Issued: 08/16/2016
• Est. Priority Date: 11/26/2012
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Leven, Jacob B.
• Primary Examiner(s): BERDICHEVSKY, AARTI
• Application Number:
  US14/076,860
• Publication Number:
  US 20140148753A1
• Time in Patent Office: 1,009 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 5/00 Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests vaccination appliances for veterinary use A61D1/025 ; tube connectors, tube couplings, valves or branch units specially adapted for medical use A61M39/00; containers specially adapted for medical or pharmaceutical purposes A61J1/00; combinations of vial and syringe for mixing or transferring their contents A61J1/20; holders for containers for collecting, storing or administering blood or medical fluids A61J1/16
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 2005/065 Light sources therefor
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue

Abstract

An electrical stimulation lead includes electrodes disposed along a distal end portion of a lead body; terminals disposed along a proximal end portion of the lead body; and stimulation conductors electrically coupling the terminals to the electrodes. A light-emitter is disposed along the distal end portion of the lead body. A light source is disposed along the at least one lead body and converts received electrical power into light. An optical transport medium is disposed along the at least one lead body. The optical transport medium extends between the light source and the light-emitter. A light source conductor electrically couples the light source and the terminals. A drug-dispensing port is defined along the distal end portion of the lead body. A drug-delivery channel is in fluid communication with the at least one drug-dispensing port and extends to the proximal end portion of the lead body.

Claims

1. An electrical stimulation lead, comprising:

at least one lead body having a distal end portion, a proximal end portion, an outer surface, and a longitudinal length;

a plurality of electrodes disposed along the distal end portion of the at least one lead body;

a plurality of terminals disposed along the proximal end portion of the at least one lead body;

a plurality of stimulation conductors, each stimulation conductor of the plurality of stimulation conductors electrically coupling each of the plurality of terminals to at least one of the plurality of electrodes;

at least one light-emitter disposed along the distal end portion of the at least one lead body, the at least one light-emitter configured and arranged for emitting received light outward from the outer surface of the at least one lead body;

at least one light source disposed along the at least one lead body, the at least one light source configured and arranged for converting received electrical power into light;

at least one optical transport medium disposed along the at least one lead body, the at least one optical transport medium having a proximal end coupled to the at least one light source and a distal end coupled to the at least one light-emitter, wherein the at least one optical transport medium is configured and arranged to transport light from the at least one light source to the at least one light-emitter; and

at least one light source conductor electrically coupled to the at least one light source and extending to the plurality of terminals.

2. The electrical stimulation lead of claim 1, wherein the at least one light source is disposed along the proximal end portion of the at least one lead body.

3. The electrical stimulation lead of claim 1, wherein the at least one light source is disposed in the at least one lead body at a location that is proximal to a proximal-most electrode of the plurality of electrodes and distal to a distal-most terminal of the plurality of terminals.

4. The electrical stimulation lead of claim 1, wherein the at least one light source is a light-emitting diode.

5. The electrical stimulation lead of claim 1, further comprising a paddle body disposed along the distal end portion of the at least one lead body.

6. The electrical stimulation lead of claim 5, wherein the plurality of electrodes are disposed along the paddle body.

7. The electrical stimulation lead of claim 5, further comprising at least one drug-dispensing port defined along the paddle body;

and

at least one drug-delivery channel in fluid communication with the at least one drug-dispensing port, the at least one drug-delivery channel extending along the longitudinal length of the at least one lead body to the paddle body.

8. The electrical stimulation lead of claim 5, wherein the at least one light-emitter is disposed along the paddle body.

9. The electrical stimulation lead of claim 1, further comprising:

at least one drug-dispensing port defined along the distal end portion of the at least one lead body; and

at least one drug-delivery channel in fluid communication with the at least one drug-dispensing port, the at least one drug-delivery channel extending along the longitudinal length of the at least one lead body to the proximal end portion of the at least one lead body.

10. An electrical stimulating system comprising:

the electrical stimulation lead of claim 9,

a control module coupleable to the electrical stimulation lead, the control module comprising

a housing, and

an electronic subassembly disposed in the housing;

a power source configured and arranged for providing power to the at least one light source via the at least one light source conductor;

a drug reservoir configured and arranged for providing drugs to the at least one drug-dispensing port via the at least one drug-delivery channel; and

a connector for receiving the electrical stimulation lead, the connector having a proximal end, a distal end, and a longitudinal length, the connector comprising

a connector housing defining a port at the distal end of the connector, the port configured and arranged for receiving the proximal end portion of the at least one lead body of the electrical stimulation lead, and

a plurality of connector contacts disposed in the connector housing, the plurality of connector contacts configured and arranged to couple to at least one of the plurality of terminals disposed on the proximal end of the at least one lead body of the electrical stimulation lead.

11. The electrical stimulation system of claim 10, wherein the power source is disposed on or in the control module.

12. The electrical stimulation system of claim 10, wherein the drug reservoir is disposed on or in the control module.

13. The electrical stimulation system of claim 10, wherein at least one of the power source or the drug reservoir is a stand-alone device that is external to the at least one lead body and physically separated from the control module.

14. The electrical stimulation system of claim 10, further comprising a pump configured and arranged to facilitate providing drugs from the drug reservoir to the at least one drug-dispensing port via the at least one drug-delivery channel.

15. A method for providing gene therapy to a patient using an electrical stimulation system, the method comprising:

advancing the electrical stimulation lead of claim 9 into the patient with the distal end portion of the at least one lead body of the electrical stimulation lead disposed in operational proximity to a target therapy location within the patient;

dispensing at least one drug from the at least one drug-dispensing port; and

emitting light from the at least one light-emitter of the electrical stimulation lead to photonically stimulate patient tissue at the target stimulation location.

16. The method of claim 15, further comprising emitting stimulation energy from the plurality of electrodes of the electrical stimulation lead to electrically stimulate patient tissue at the target stimulation location.

17. The method of claim 15, wherein advancing the electrical stimulation lead of claim 1 into the patient comprises using the plurality of electrodes of the electrical stimulation lead to facilitate advancement of the electrical stimulation lead.

18. An electrical stimulation lead, comprising:

at least one lead body having a distal end portion, a proximal end portion, an outer surface, and a longitudinal length;

a plurality of electrodes disposed along the distal end portion of the at least one lead body;

a plurality of terminals disposed along the proximal end portion of the at least one lead body;

a plurality of stimulation conductors, each stimulation conductor of the plurality of stimulation conductors electrically coupling each of the plurality of terminals to at least one of the plurality of electrodes;

at least one light-emitter disposed along the distal end portion of the at least one lead body, the at least one light-emitter configured and arranged for receiving power, converting the received power to light, and emitting the converted light outward from the outer surface of the at least one lead body;

at least one light source conductor coupled to the at least one light-emitter and extending to the plurality of terminals;

at least one drug-dispensing port defined along the distal end portion of the at least one lead body; and

at least one drug-delivery channel in fluid communication with the at least one drug-dispensing port, the at least one drug-delivery channel extending along the longitudinal length of the at least one lead body to the proximal end portion of the at least one lead body.

19. The electrical stimulation lead of claim 18 wherein the at least one light emitter is a light-emitting diode.

20. An electrical stimulation lead assembly, comprising:

an electrical stimulation lead comprising

at least one lead body having a distal end portion, a proximal end portion, an outer surface, and a longitudinal length,

a paddle body disposed along the distal end portion of the at least one lead body;

a plurality of electrodes disposed on a surface of the paddle body,

a plurality of terminals disposed along the proximal end portion of the at least one lead body,

a plurality of stimulation conductors, each stimulation conductor of the plurality of stimulation conductors electrically coupling each of the plurality of terminals to at least one of the plurality of electrodes,

at least one light-emitter disposed along the paddle body, the at least one light-emitter configured and arranged for emitting received light outward from the surface of the paddle body,

at least one optical transport medium disposed along the at least one lead body, the at least one optical transport medium having a distal end coupled to the at least one light-emitter and a proximal end extending to the proximal end portion of the at least one lead body, wherein the at least one optical transport medium is configured and arranged to transport light,

at least one drug-dispensing port defined along the surface of the paddle body, and

at least one drug-delivery channel in fluid communication with the at least one drug-dispensing port, the at least one drug-delivery channel extending along the longitudinal length of the at least one lead body to the proximal end portion of the at least one lead body; and

at least one light source disposed external to the at least one lead body and in communication with the at least one optical transport medium, the at least one light source configured and arranged for generating light, the at least one light source coupled to the at least one light-emitter via the at least one optical transport medium.