Process for making hydroxylated cyclopentylpyrimidine compounds

• US 9,416,110 B2
• Filed: 05/17/2013
• Issued: 08/16/2016
• Est. Priority Date: 05/17/2012
• Status: Active Grant

• Current Assignee: Array Biopharma Incorporated (Pfizer Inc.), Genentech, Inc. (Roche Holding AG)
• Original Assignee: Array Biopharma Incorporated (Pfizer Inc.), Genentech, Inc. (Roche Holding AG)
• Inventors: Askin, David, Han, Chong, Lane, Jonathan W., Remarchuk, Travis, Shakya, Sagar, Sowell, C. Gregory, Spencer, Keith L., Stengel, Peter J.
• Primary Examiner(s): Murray, Jeffrey H
• Application Number:
  US14/401,087
• Publication Number:
  US 20150152067A1
• Time in Patent Office: 1,187 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 239/30 Halogen atoms or nitro radicals
• CPC Class Codes: C07D 239/42 One nitrogen atom nitro radicals C07D239/30
• CPC Class Codes: C07D 239/70 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The invention provides processes for preparing a compound of formula I and salts thereof, wherein R¹ is defined herein, and compounds and intermediates of said formula.

Claims

1. A compound of formula IV:

2. The compound of claim 1, wherein R² is —

C(O)N(R^a)OR^c.

3. The compound of claim 1, wherein each R³ is iodo.

4. The compound of claim 1, which is the compound: