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Fibronectin binding domains with reduced immunogenicity

  • US 9,416,170 B2
  • Filed: 02/01/2013
  • Issued: 08/16/2016
  • Est. Priority Date: 10/31/2011
  • Status: Active Grant
First Claim
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1. A polypeptide comprising a human fibronectin type 3 tenth (10Fn3) domain, which comprises AB, BC, CD, DE, EF, and FG loops and β

  • -strands A, B, C, D, E, F, and G, wherein the 10Fn3 domain comprises modifications only in the amino acid sequence of the FG loop relative to the FG loop of the wild-type human 10Fn3 domain as set forth in SEQ ID NO;

    6, and in the amino acid sequence of the CD loop relative to the corresponding loop of the wild-type human 10Fn3 domain as set forth in SEQ ID NO;

    6, wherein the modifications contribute to binding a target.

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