Stereo data representation of biomedical signals along a lead

• US 9,420,960 B2
• Filed: 04/20/2011
• Issued: 08/23/2016
• Est. Priority Date: 10/21/2010
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Lazarewicz, Maciej T., Molnar, Gabriela C., Dixon, Jeffrey R., McConnell, Deborah A.
• Primary Examiner(s): PATTON, AMANDA K
• Application Number:
  US13/090,658
• Publication Number:
  US 20120101552A1
• Time in Patent Office: 1,952 Days
• Field of Search: 607/32, 607/62
• US Class Current: 1/1
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

Various embodiments concern sensing bioelectrical signals using electrodes along a lead, the electrodes having a spatial configuration along the lead, generating signal data sets, one signal data set being generated for each bioelectrical signal, and graphically representing the electrodes and data representations of the signal data sets on a display. In various embodiments, each data representation indicates a parameter of a respective one of the data sets, the electrodes are graphically represented on the display in a spatial configuration representative of the spatial configuration of the electrodes along the lead, and each data representation is graphically represented on the display in spatial association with at least one electrode through which the bioelectrical signal on which the signal data set is based was sensed. The parameter can be indicative of the relative presence of a biomarker in the bioelectrical signals.

Claims

1. A method of stereo data representation along a sensing lead, the method comprising:

sensing a plurality of bioelectrical signals using a plurality of electrodes along a lead, the plurality of electrodes having a spatial configuration along the lead;

generating a plurality of signal data sets, one signal data set being generated for each bioelectrical signal of the plurality of bioelectrical signals; and

graphically representing the electrodes and a plurality of data representations of the signal data sets on a display, wherein each data representation of the plurality indicates a parameter of a respective one of the plurality of data sets, wherein the electrodes are graphically represented on the display in a spatial configuration representative of the spatial configuration of the plurality of electrodes along the lead, wherein each data representation is graphically represented on the display in spatial association with at least one electrode of an electrode combination through which the bioelectrical signal on which the signal data set is based was sensed, wherein each data representation comprises an electrode combination indicator that identifies the electrode combination through which the bioelectrical signal on which the data representation is based was sensed, and wherein generating and graphically representing are each performed at least in part by medical device control circuitry.

2. The method of claim 1, wherein generating the plurality of signal data sets comprises determining the relative presence of a biomarker in each of the plurality of bioelectrical signals and wherein the parameter is indicative of the relative presence of the biomarker.

3. The method of claim 2, wherein the biomarker comprises one or both of beta band power content and gamma band power content.

4. The method of claim 2, wherein the data representations indicate the parameter by one or more of color, value, or line pattern, and wherein the color, value, or line pattern is variable based on the relative presence of the biomarker.

5. The method of claim 1, wherein:

each of the plurality of bioelectrical signals is sensed using a different electrode combination of the plurality of electrodes; and

each data representation is graphically represented on the display in spatial association with the electrode combination through which the bioelectrical signal on which the parameter of the data representation is based was sensed.

6. The method of claim 1, wherein:

generating the plurality of signal data sets comprises generating a plurality of traces, each trace of the plurality generated from a respective one of the plurality of bioelectrical signals; and

graphically representing the data representations comprises graphically representing the traces.

7. The method of claim 1, wherein each electrode combination indicator comprises a line between two of the electrode representations from which the bioelectrical signal on which the data representation is based was sensed.

8. The method of claim 1, wherein each data representation comprises at least one parameter of stimulation output.

9. The method of claim 1, further comprising comparing the data sets of the plurality of data sets to each other, wherein graphically representing the data representations comprises only displaying a number of data representations of those data sets that are associated with greater sensing of a particular signal component relative to others of the signal data sets based on the comparison, wherein the number is at least two.

10. The method of claim 1, furthering comprising determining a spatial positioning of the lead in a human brain, wherein graphically representing the electrodes and the data representations on the display further comprises graphically representing an anatomical brain model on the display and graphically representing the electrodes in spatial association with the anatomical brain model representing the spatial positioning of the lead in the human brain.

11. The method of claim 1, wherein each data representation of each signal data set is graphically represented on the display in proximate spatial association with the electrode on which the signal data set is based such that the closest data representation on the display to any electrode is the data representation that is based on the bioelectrical signal sensed using the electrode.

12. The method of claim 1, wherein each data representation is graphically represented on the display in proximate spatial association with the electrode combination on which a associated signal data set is based such that the closest data representation on the display to any electrode combination is the data representation that is based on the bioelectrical signal sensed using the electrode combination.

13. The method of claim 1, wherein the lead is configured to be coupled with an implantable medical device.

14. A system comprising:

a lead having a plurality of electrodes, the plurality of electrodes having a spatial configuration along the lead;

a display; and

control circuitry, the control circuitry configured to;

sense a plurality of bioelectrical signals using the plurality of electrodes;

generate a plurality of signal data sets, one signal data set being generated for each bioelectrical signal of the plurality of bioelectrical signals; and

graphically represent the electrodes and a plurality of data representations of the signal data sets on the display, wherein the control circuitry is configured to graphically represent the electrodes and the plurality of data representations such that each data representation of the plurality indicates a parameter of a respective one of the plurality of data sets, the electrodes are graphically represented on the display in a spatial configuration representative of the spatial configuration of the plurality of electrodes of the lead, and each data representation is graphically represented on the display in spatial association with at least one electrode of an electrode combination through which the bioelectrical signal on which the signal data set is based was sensed, and wherein each data representation comprises an electrode combination indicator which identifies the electrode combination through which the bioelectrical signal on which the data representation is based was sensed.

15. The system of claim 14, wherein generation of the signal data sets by the control circuitry comprises determining the relative presence of a biomarker in each of the plurality of bioelectrical signals, and wherein the parameter is indicative of the relative presence of the biomarker.

16. The system of claim 15, wherein the biomarker comprises one or both of beta band power content and gamma band power content.

17. The system of claim 15, wherein the parameter is indicated for each data representation by one or more of color, value, and line pattern, and wherein the color, value, and line pattern are each variable based on the relative presence of the biomarker.

18. The system of claim 14, wherein the control circuitry is configured to:

sense each of the plurality of bioelectrical signals using a different electrode combination of the plurality of electrodes;

graphically represent each data representation on the display in spatial association with the electrode combination with which the bioelectrical signal on which the parameter of the data representation is based was sensed.

19. The system of claim 14, wherein the control circuitry is configured to:

generate a plurality of traces as a part of generating the plurality of signal data sets, each trace of the plurality generated from a respective one of the plurality of bioelectrical signals; and

graphically represent the traces as part of graphically representing the data representations.

20. The system of claim 14, wherein each electrode combination indicator comprises a line between two of the electrode representations from which the bioelectrical signal on which the data representation is based was sensed.

21. The system of claim 14, wherein:

the control circuitry is further configured to deliver electrical stimulation from the plurality of electrodes;

the control circuitry is further configured to sense the plurality of bioelectrical signals timed to collect include invoked response data; and

each data representation indicates a first parameter of a stimulation output parameter and a second parameter indicative of the invoked response data.

22. The system of claim 14, wherein the control circuitry is further configured to:

compare the data sets of the plurality of data sets to each other; and

graphically represent the data representations such that only a number of data representations of those data sets that are associated with greater sensing of a particular signal component relative to others of the signal data sets based on the comparison are displayed, wherein the number is at least two.

23. The system of claim 14, wherein the control circuitry is further configured to:

determine a spatial positioning of the lead in a human brain; and

graphically represent an anatomical brain model on the display and graphically represent the electrodes in spatial association with the anatomical brain model representing the spatial positioning of the lead in the human brain.

24. The system of claim 14, wherein the control circuitry is configured to graphically represent each data representation of each signal data set on the display in proximate spatial association with the electrode on which the signal data set is based such that the closest data representation on the display to any electrode is the data representation that is based on the bioelectrical signal sensed using the electrode.

25. The system of claim 14, wherein the control circuitry is configured to graphically represent each data representation on the display in proximate spatial association with the electrode combination on which an associated signal data set is based such that the closest data representation on the display to any electrode combination is the data representation that is based on the bioelectrical signal sensed using the electrode combination.

26. The system of claim 14, wherein the lead is configured to be coupled with an implantable medical device.

27. A system comprising:

means for sensing a plurality of bioelectrical signals using a plurality of electrodes along a lead, the plurality of electrodes having a spatial configuration along the lead;

means for generating a plurality of signal data sets, one signal data set being generated for each bioelectrical signal of the plurality of bioelectrical signals; and

means for graphically representing the electrodes and a plurality of data representations of the signal data sets on a display, wherein each data representation of the plurality indicates a parameter of a respective one of the plurality of data sets, wherein the electrodes are graphically represented on the display in a spatial configuration representative of the spatial configuration of the plurality of electrodes along the lead, wherein each data representation is graphically represented on the display in spatial association with at least one electrode of an electrode combination through which the bioelectrical signal on which the signal data set is based was sensed, wherein each data representation comprises an electrode combination indicator which identifies the electrode combination through which the bioelectrical signal on which the data representation is based was sensed, and wherein generating and graphically representing are each performed at least in part by a processor.

28. The system of claim 27, wherein the means for generating the plurality of signal data sets comprises means for determining the relative presence of a biomarker in each of the plurality of bioelectrical signals and wherein the parameter is indicative of the relative presence of the biomarker.

29. A computer readable medium comprising instructions for causing a medical device to perform steps comprising:

sensing a plurality of bioelectrical signals using a plurality of electrodes along a lead, the plurality of electrodes having a spatial configuration along the lead;

generating a plurality of signal data sets at least in part by determining the relative presence of a biomarker in each of the plurality of bioelectrical signals, one signal data set being generated for each bioelectrical signal of the plurality of bioelectrical signals; and

graphically representing the electrodes and a plurality of data representations of the signal data sets on a display, wherein each data representation of the plurality indicates a parameter of a respective one of the plurality of data sets and the parameter is indicative of the relative presence of the biomarker, wherein the electrodes are graphically represented on the display in a spatial configuration representative of the spatial configuration of the plurality of electrodes along the lead, and wherein each data representation is graphically represented on the display in spatial association with at least one electrode of an electrode combination through which the bioelectrical signal on which the signal data set is based was sensed, wherein each data representation comprises an electrode combination indicator which identifies the electrode combination through which the bioelectrical signal on which the data representation is based was sensed, and wherein generating and graphically representing are each performed at least in part by a processor.